Rockwood G A, Riley E P
Teratology. 1986 Apr;33(2):145-51. doi: 10.1002/tera.1420330202.
With the aid of a pair-feeding procedure, two groups of pregnant Long-Evans rats were fed a liquid diet containing 35% or 0% ethanol-derived calories during days 6-20 of gestation. A third group was allowed free access to standard lab chow and water throughout pregnancy. At 6-7 or 9-10 days of age, suckling performance by male and female offspring representing the three prenatal treatment groups was examined. The test stimulus was a 6-10-day postparturient, anesthetized dam in which milk letdown was prevented. Compared to both pair-fed and lab chow controls, alcohol-exposed animals exerted a lower maximum suckling pressure, spent less time suckling during the test session, and displayed an altered suckling pattern. These data are consistent with existing clinical and experimental evidence documenting sucking deficits following prenatal alcohol exposure and are discussed in terms of prenatal alcohol-induced CNS impairment.
借助配对喂养程序，在妊娠第6至20天，两组怀孕的Long-Evans大鼠被喂食含有35%或0%乙醇衍生热量的流质饮食。第三组在整个孕期可自由获取标准实验室饲料和水。在出生后6至7天或9至10天，对代表三个产前治疗组的雄性和雌性后代的哺乳性能进行了检查。测试刺激是一只产后6至10天、麻醉的母鼠，其乳汁排出受到抑制。与配对喂养和实验室饲料对照组相比，暴露于酒精的动物表现出较低的最大吸吮压力，在测试期间吸吮时间较短，并且显示出改变的吸吮模式。这些数据与现有临床和实验证据一致，这些证据记录了产前酒精暴露后的吸吮缺陷，并从产前酒精诱导的中枢神经系统损伤方面进行了讨论。
