Meyer L S, Riley E P
Teratology. 1986 Aug;34(1):1-7. doi: 10.1002/tera.1420340102.
Offspring of rat dams that consumed isocaloric liquid diets containing either 35% or 0% ethanol-derived calories (EDC) from gestation days 6-20 were tested for play-fighting behavior as juveniles. Offspring from a group of dams maintained on standard lab chow and water throughout gestation were also included. Animals were tested in pairs, with offspring from each of the three prenatal treatment conditions (35% EDC, 0% EDC, and lab chow) being paired with another same-sex animal from one of these three prenatal treatment groups. Although play-fighting in juveniles is normally sexually dimorphic, this normal pattern was absent in juveniles prenatally exposed to alcohol. Male alcohol-exposed offspring displayed feminized behavior while female alcohol-exposed offspring showed masculinized behavior. This reversal of the normal sexually dimorphic aspects of play suggests that some of the behavioral disturbances associated with prenatal alcohol exposure may result, in part, from an alcohol-induced disruption of the hormonal environment in which the fetus develops.
在妊娠第6至20天食用含有35%或0%乙醇衍生热量（EDC）的等热量液体饮食的大鼠母鼠的后代，在幼年时接受了打闹行为测试。还包括一组在整个妊娠期以标准实验室饲料和水喂养的母鼠的后代。动物成对进行测试，来自三种产前处理条件（35% EDC、0% EDC和实验室饲料）的每一种的后代都与来自这三个产前处理组之一的另一只同性动物配对。虽然幼年大鼠的打闹行为通常具有性别差异，但在产前接触酒精的幼年大鼠中，这种正常模式并不存在。雄性酒精暴露后代表现出女性化行为，而雌性酒精暴露后代表现出男性化行为。这种正常性别差异行为的逆转表明，一些与产前酒精暴露相关的行为障碍可能部分是由于酒精对胎儿发育所处激素环境的干扰所致。
