St Claire Kayla, Edriss Manar, Potts Geoffrey A
Dermatology, Wayne State University School of Medicine, Detroit, USA.
Internal Medicine, St. Joseph Mercy Ann Arbor Hospital, Ypsilanti, USA.
Cureus. 2023 May 28;15(5):e39617. doi: 10.7759/cureus.39617. eCollection 2023 May.
Rosai-Dorfman disease (RDD) is a rare benign non-Langerhans cell histiocytosis. The most common site of extranodal involvement is the skin. Cutaneous involvement without lymphadenopathy is extremely rare. It is often difficult to diagnose primary cutaneous RDD secondary to the non-specific nature of its clinical and histologic features. Consequently, diagnosis can be significantly delayed. To our knowledge, about 220 reports of purely cutaneous RDD are documented in the literature to date. We present an additional unique case of cutaneous RDD and emphasize the challenging nature of accurate clinical and histopathologic diagnosis.
罗萨伊-多夫曼病（RDD）是一种罕见的良性非朗格汉斯细胞组织细胞增多症。结外受累最常见的部位是皮肤。无淋巴结病的皮肤受累极为罕见。由于其临床和组织学特征的非特异性，原发性皮肤RDD往往难以诊断。因此，诊断可能会显著延迟。据我们所知，迄今为止，文献中记录了约220例纯皮肤RDD的报告。我们报告了一例额外的独特皮肤RDD病例，并强调了准确临床和组织病理学诊断的挑战性。
