Winkelman L, Haddon M E
Thromb Res. 1986 Jul 15;43(2):219-27. doi: 10.1016/0049-3848(86)90063-0.
The changes that take place when a therapeutic antithrombin III (AT III) concentrate is heated in the presence of citrate ion have been assessed. There is some loss of heparin cofactor antithrombin activity and of heparin binding ability. Protein aggregates are also formed during heating. These aggregates are not AT III but impurities in the concentrate.
已评估了治疗用抗凝血酶III（AT III）浓缩物在枸橼酸根离子存在下加热时所发生的变化。肝素辅因子抗凝血酶活性和肝素结合能力会有一定损失。加热过程中还会形成蛋白质聚集体。这些聚集体不是AT III，而是浓缩物中的杂质。
