Park K, Gerndt S J, Cooper S L
Thromb Res. 1986 Aug 1;43(3):293-302. doi: 10.1016/0049-3848(86)90149-0.
The effect of fibrinogen sialic acid residues on platelet deposition onto polymer surfaces was examined using a canine ex vivo shunt model. To test the hypothesis that desialylated fibrinogen may enhance platelet deposition when precoated on biomaterials, canine fibrinogen was desialylated and precoated on polyvinyl chloride (PVC) shunts. When protein-coated PVC shunts were exposed to flowing whole blood, both the native and the desialylated fibrinogen elicited the same profile of platelet deposition. This study indicates that platelet deposition and thrombus formation on biomaterial surfaces is not mediated by a mechanism which involves the sialic acid residues of fibrinogen.
使用犬类体外分流模型研究了纤维蛋白原唾液酸残基对血小板在聚合物表面沉积的影响。为了验证去唾液酸化纤维蛋白原预涂覆在生物材料上可能会增强血小板沉积这一假设，对犬类纤维蛋白原进行去唾液酸化处理，并预涂覆在聚氯乙烯（PVC）分流器上。当蛋白质包被的PVC分流器暴露于流动的全血时，天然纤维蛋白原和去唾液酸化纤维蛋白原引发的血小板沉积情况相同。本研究表明，生物材料表面的血小板沉积和血栓形成并非由涉及纤维蛋白原唾液酸残基的机制介导。
