在肌张力障碍患儿的自主运动过程中，苍白球内侧部活动增强。
Globus pallidus internus activity increases during voluntary movement in children with dystonia.
作者信息
Hernandez-Martin Estefania, Kasiri Maral, Abe Sumiko, MacLean Jennifer, Olaya Joffre, Liker Mark, Chu Jason, Sanger Terence D
机构信息
Department of Electrical Engineering and Computer Science, University of California, Irvine, Irvine, CA, USA.
Department of Biomedical Engineering, University of California, Irvine, Irvine, CA, USA.
出版信息
iScience. 2023 Jun 7;26(7):107066. doi: 10.1016/j.isci.2023.107066. eCollection 2023 Jul 21.
The rate model of basal ganglia function predicts that muscle activity in dystonia is due to disinhibition of thalamus resulting from decreased inhibitory input from pallidum. We seek to test this hypothesis in children with dyskinetic cerebral palsy undergoing evaluation for deep brain stimulation (DBS) to analyze movement-related activity in different brain regions. The results revealed prominent beta-band frequency peaks in the globus pallidus interna (GPi), ventral oralis anterior/posterior (VoaVop) subnuclei of the thalamus, and subthalamic nucleus (STN) during movement but not at rest. Connectivity analysis indicated stronger coupling between STN-VoaVop and STN-GPi compared to GPi-STN. These findings contradict the hypothesis of decreased thalamic inhibition in dystonia, suggesting that abnormal patterns of inhibition and disinhibition, rather than reduced GPi activity, contribute to the disorder. Additionally, the study implies that correcting abnormalities in GPi function may explain the effectiveness of DBS targeting the STN and GPi in treating dystonia.
基底神经节功能的速率模型预测，肌张力障碍中的肌肉活动是由于苍白球抑制性输入减少导致丘脑去抑制所致。我们试图在接受深部脑刺激（DBS）评估的运动障碍型脑瘫儿童中验证这一假设，以分析不同脑区与运动相关的活动。结果显示，在运动过程中，内侧苍白球（GPi）、丘脑腹前/后核（VoaVop）和底丘脑核（STN）出现明显的β波段频率峰值，而在静息状态下则未出现。连通性分析表明，与GPi-STN相比，STN-VoaVop和STN-GPi之间的耦合更强。这些发现与肌张力障碍中丘脑抑制减少的假设相矛盾，表明抑制和去抑制的异常模式，而非GPi活动减少，导致了该疾病。此外，该研究表明，纠正GPi功能异常可能解释了DBS靶向STN和GPi治疗肌张力障碍的有效性。
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