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Genetic factors in methylmercury-induced neurotoxicity: What have we learned from models?甲基汞诱导神经毒性中的遗传因素：我们从模型中学到了什么？
Adv Neurotoxicol. 2023;9:271-290. doi: 10.1016/bs.ant.2023.01.006. Epub 2023 Mar 13.
2
Developmental Methylmercury Exposure Induced and Age-Dependent Glutamatergic Neurotoxicity in Caenorhabditis elegans.发育性甲基汞暴露诱导的和年龄依赖性的秀丽隐杆线虫谷氨酸能神经毒性。
Neurochem Res. 2023 Mar;48(3):920-928. doi: 10.1007/s11064-022-03816-5. Epub 2022 Nov 16.
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Methylmercury exposure-induced reproductive effects are mediated by dopamine in Caenorhabditis elegans.甲基汞暴露诱导的生殖效应是通过秀丽隐杆线虫中的多巴胺介导的。
Neurotoxicol Teratol. 2022 Sep-Oct;93:107120. doi: 10.1016/j.ntt.2022.107120. Epub 2022 Aug 17.
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The Modulatory Role of sti-1 in Methylmercury-Induced Toxicity in Caenorhabditis elegans.sti-1在甲基汞诱导的秀丽隐杆线虫毒性中的调节作用
Neurotox Res. 2022 Jun;40(3):837-846. doi: 10.1007/s12640-022-00515-5. Epub 2022 Apr 26.
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Chronic exposure to methylmercury induces puncta formation in cephalic dopaminergic neurons in Caenorhabditis elegans.慢性甲基汞暴露诱导秀丽隐杆线虫头部多巴胺神经元形成点状结构。
Neurotoxicology. 2020 Mar;77:105-113. doi: 10.1016/j.neuro.2020.01.003. Epub 2020 Jan 11.
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The Human LRRK2 Modulates the Age-Dependent Effects of Developmental Methylmercury Exposure in Caenorhabditis elegans.人类 LRRK2 调节秀丽隐杆线虫中发育性甲基汞暴露的年龄依赖性效应。
Neurotox Res. 2022 Oct;40(5):1235-1247. doi: 10.1007/s12640-022-00547-x. Epub 2022 Jul 15.
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Insights into cisplatin-induced neurotoxicity and mitochondrial dysfunction in Caenorhabditis elegans.顺铂诱导的秀丽隐杆线虫神经毒性和线粒体功能障碍的研究进展。
Dis Model Mech. 2022 Mar 1;15(3). doi: 10.1242/dmm.049161. Epub 2022 Mar 31.
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The putative multidrug resistance protein MRP-7 inhibits methylmercury-associated animal toxicity and dopaminergic neurodegeneration in Caenorhabditis elegans.假定的多药耐药蛋白 MRP-7 可抑制甲基汞相关的动物毒性和秀丽隐杆线虫中的多巴胺能神经退行性变。
J Neurochem. 2014 Mar;128(6):962-74. doi: 10.1111/jnc.12515. Epub 2013 Nov 25.
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Cephalic Neuronal Vesicle Formation is Developmentally Dependent and Modified by Methylmercury and sti-1 in Caenorhabditis elegans.头神经元囊泡的形成是发育依赖性的，并受甲基汞和 sti-1 在秀丽隐杆线虫中的修饰。
Neurochem Res. 2020 Dec;45(12):2939-2948. doi: 10.1007/s11064-020-03142-8. Epub 2020 Oct 10.
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Therapeutic Efficacy of the N,N' Bis-(2-Mercaptoethyl) Isophthalamide Chelator for Methylmercury Intoxication in Caenorhabditis elegans.N,N'-双-(2-巯基乙基)间苯二甲酰胺螯合剂对秀丽隐杆线虫甲基汞中毒的治疗效果。
Neurotox Res. 2020 Jun;38(1):133-144. doi: 10.1007/s12640-020-00194-0. Epub 2020 Mar 31.

引用本文的文献

1
Sediment mercury and methylmercury dynamics during reservoir operation.水库运行期间沉积物汞和甲基汞的动态变化
Sci Rep. 2025 May 23;15(1):18011. doi: 10.1038/s41598-025-03255-6.
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Machine learning-based analysis of microfluidic device immobilized C. elegans for automated developmental toxicity testing.基于机器学习的微流控装置固定秀丽隐杆线虫用于自动化发育毒性测试的分析
Sci Rep. 2025 Jan 2;15(1):15. doi: 10.1038/s41598-024-84842-x.
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vivoBodySeg: Machine learning-based analysis of C. elegans immobilized in vivoChip for automated developmental toxicity testing.体内线虫身体分割：基于机器学习对固定在体内芯片中的秀丽隐杆线虫进行分析，用于自动化发育毒性测试。
Res Sq. 2024 Sep 4:rs.3.rs-4796642. doi: 10.21203/rs.3.rs-4796642/v1.
4
as an emerging model in neurotoxicology.作为神经毒理学中的一种新兴模型。
Adv Neurotoxicol. 2023;9:181-196. doi: 10.1016/bs.ant.2023.01.004. Epub 2023 Feb 27.

本文引用的文献

1
The Human LRRK2 Modulates the Age-Dependent Effects of Developmental Methylmercury Exposure in Caenorhabditis elegans.人类 LRRK2 调节秀丽隐杆线虫中发育性甲基汞暴露的年龄依赖性效应。
Neurotox Res. 2022 Oct;40(5):1235-1247. doi: 10.1007/s12640-022-00547-x. Epub 2022 Jul 15.
2
Methyl mercury: loaves versus fishes.甲基汞：面包与鱼。
Neurotoxicology. 2020 Dec;81:282-287. doi: 10.1016/j.neuro.2020.09.018. Epub 2020 Oct 14.
3
Asymmetric inheritance of RNA toxicity in expressing CTG repeats.表达CTG重复序列时RNA毒性的不对称遗传
iScience. 2022 Apr 11;25(5):104246. doi: 10.1016/j.isci.2022.104246. eCollection 2022 May 20.
4
Ghrelin attenuates methylmercury-induced oxidative stress in neuronal cells.胃饥饿素可减轻甲基汞诱导的神经元细胞氧化应激。
Mol Neurobiol. 2022 Apr;59(4):2098-2115. doi: 10.1007/s12035-022-02726-5. Epub 2022 Jan 18.
5
Developmental Exposure to Low Concentrations of Methylmercury Causes Increase in Anxiety-Related Behaviour and Locomotor Impairments in Zebrafish.发育暴露于低浓度甲基汞会导致斑马鱼出现焦虑相关行为和运动障碍。
Int J Mol Sci. 2021 Oct 11;22(20):10961. doi: 10.3390/ijms222010961.
6
Neurodegenerative Disease: Roles for Sex, Hormones, and Oxidative Stress.神经退行性疾病：性别、激素和氧化应激的作用。
Endocrinology. 2021 Nov 1;162(11). doi: 10.1210/endocr/bqab185.
7
The Role of Human LRRK2 in Acute Methylmercury Toxicity in Caenorhabditis elegans.人类 LRRK2 在秀丽隐杆线虫急性甲基汞毒性中的作用。
Neurochem Res. 2021 Nov;46(11):2991-3002. doi: 10.1007/s11064-021-03394-y. Epub 2021 Jul 16.
8
Ecotoxicity Risk of Low-Dose Methylmercury Exposure to : Multigenerational Toxicity and Population Discrepancy.低剂量甲基汞暴露对的生态毒性风险：多代毒性和种群差异。
Chem Res Toxicol. 2021 Apr 19;34(4):1114-1123. doi: 10.1021/acs.chemrestox.0c00518. Epub 2021 Mar 19.
9
Stress resets ancestral heritable small RNA responses.应激重置祖先可遗传的小 RNA 反应。
Elife. 2021 Mar 17;10:e65797. doi: 10.7554/eLife.65797.
10
Latent alterations in swimming behavior by developmental methylmercury exposure are modulated by the homolog of tyrosine hydroxylase in Caenorhabditis elegans.发育性甲基汞暴露导致的游泳行为潜在改变受秀丽隐杆线虫酪氨酸羟化酶同源物的调节。
Neurotoxicol Teratol. 2021 May-Jun;85:106963. doi: 10.1016/j.ntt.2021.106963. Epub 2021 Feb 21.

Genetic factors in methylmercury-induced neurotoxicity: What have we learned from models?

作者信息

Ke Tao, Junior Fernando Barbosa, Santamaria Abel, Bowman Aaron B, Aschner Michael

机构信息

Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, United States.

Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.

出版信息

Adv Neurotoxicol. 2023;9:271-290. doi: 10.1016/bs.ant.2023.01.006. Epub 2023 Mar 13.

DOI:10.1016/bs.ant.2023.01.006
PMID:37389202
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10310048/
Abstract
摘要