Patterson J R, Grabois M
Stroke. 1986 Jul-Aug;17(4):758-64. doi: 10.1161/01.str.17.4.758.
Etiology, clinical manifestations and outcome were reviewed in 139 cases of "locked-in syndrome." Six cases were reported from our center and the remaining 133 cases were taken from a review of the literature. The results of this review emphasized the necessity for a comprehensive program of pulmonary management in this population. Furthermore, an effective system of communication for the patient is considered essential in the management of the "locked-in" state. Reported mortality in the cases reviewed was 60%. Overall, the prognosis for survival and recovery was found to be better in the group of patients whose syndrome was nonvascular in origin than those with a vascular etiology. Functional recovery was generally good in those patients with a vascular etiology who survived beyond 4 months while recovery occurred earlier and more completely in the nonvascular group. Thus, a program of intensive rehabilitation should be considered early in both groups in order to assist each patient in attaining the highest level of function possible as recovery progresses.
对139例“闭锁综合征”患者的病因、临床表现及预后进行了回顾。其中6例来自我们中心，其余133例取自文献综述。该综述结果强调了对这一人群实施全面肺部管理方案的必要性。此外，在“闭锁”状态的管理中，为患者建立有效的沟通系统被认为至关重要。在所回顾的病例中，报告的死亡率为60%。总体而言，发现综合征起源于非血管性的患者组的生存和恢复预后优于血管性病因的患者组。血管性病因的患者若存活超过4个月，功能恢复通常良好，而非血管性组恢复更早且更完全。因此，两组均应尽早考虑强化康复方案，以便随着恢复进程帮助每位患者尽可能达到最高功能水平。
