Lim Ee Jean, Yen Jie, Fong Khi Yung, Tiong Ho Yee, Aslim Edwin Jonathan, Ng Lay Guat, Castellani Daniele, Borgheresi Alessandra, Agostini Andrea, Somani Bhaskar Kumar, Gauhar Vineet, Gan Valerie Huei Li
Department of Urology, Singapore General Hospital, Singapore.
Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Transplantation. 2024 Mar 1;108(3):643-653. doi: 10.1097/TP.0000000000004711. Epub 2024 Feb 20.
Radiomics is increasingly applied to the diagnosis, management, and outcome prediction of various urological conditions. The purpose of this scoping review is to evaluate the current evidence of the application of radiomics in kidney transplantation, especially its utility in diagnostics and therapeutics. An electronic literature search on radiomics in the setting of transplantation was conducted on PubMed, EMBASE, and Scopus from inception to September 23, 2022. A total of 16 studies were included. The most widely studied clinical utility of radiomics in kidney transplantation is its use as an adjunct to diagnose rejection, potentially reducing the need for unnecessary biopsies or guiding decisions for earlier biopsies to optimize graft survival. Technology such as optical coherence tomography is a noninvasive procedure to build high-resolution optical cross-section images of the kidney cortex in situ and in real time, which can provide histopathological information of donor kidney candidates for transplantation, and to predict posttransplant function. This review shows that, although radiomics in kidney transplants is still in its infancy, it has the potential for large-scale implementation. Its greatest potential lies in the correlation with conventional established diagnostic evaluation for living donors and potential in predicting and detecting rejection postoperatively.
放射组学越来越多地应用于各种泌尿系统疾病的诊断、管理和预后预测。本综述的目的是评估放射组学在肾移植中应用的现有证据，尤其是其在诊断和治疗方面的效用。从创刊到2022年9月23日，在PubMed、EMBASE和Scopus上对移植领域的放射组学进行了电子文献检索。共纳入16项研究。放射组学在肾移植中研究最广泛的临床效用是作为诊断排斥反应的辅助手段，有可能减少不必要的活检需求或指导早期活检决策以优化移植物存活。光学相干断层扫描等技术是一种无创程序，可在原位实时构建肾皮质的高分辨率光学横截面图像，它可以提供供肾移植候选人的组织病理学信息，并预测移植后功能。本综述表明，尽管肾移植中的放射组学仍处于起步阶段，但它具有大规模应用的潜力。其最大的潜力在于与活体供体的传统既定诊断评估相关联，以及在预测和检测术后排斥反应方面的潜力。
