Department of Biomedical Sciences, School of Bio-Sciences and Technology, Vellore Institute of Technology (VIT), Vellore, Tamil Nadu 632014, India.
Department of Biomedical Sciences, School of Bio-Sciences and Technology, Vellore Institute of Technology (VIT), Vellore, Tamil Nadu 632014, India.
J Reprod Immunol. 2023 Aug;158:103984. doi: 10.1016/j.jri.2023.103984. Epub 2023 Jun 26.
The male reproductive system, particularly the male gamete, offers a unique barrier to the immune system. The growing germ cells in the testis need to be shielded from autoimmune damage. Hence the testis has to establish and sustain an immune-privileged milieu. Sertoli cells create this safe space, protected by the blood-testis barrier. Cytokines are a type of immune reaction that can positively and negatively affect male reproductive health. Inflammation, disease, and obesity are just a few physiological conditions for which cytokines mediate signals. They interact with steroidogenesis, shaping the adrenals and testes to produce the hormones needed for survival. In particular pathological condition, including autoimmune disorders, contains high levels of the same cytokines in semen that play an essential role in the immunomodulation of the male gonad. This review focuses on understanding the immunological role of cytokines in the control and development of male reproduction. Also, in maintaining male reproductive health and diseases linked with their aberrant function in the testis.
男性生殖系统，特别是男性配子，为免疫系统提供了一个独特的屏障。睾丸中不断生长的生殖细胞需要免受自身免疫的损害。因此，睾丸必须建立和维持一个免疫特惠环境。支持细胞创造了这个安全的空间，受到血睾屏障的保护。细胞因子是一种免疫反应，可以积极和消极地影响男性生殖健康。炎症、疾病和肥胖只是细胞因子介导信号的几种生理状况。它们与类固醇生成相互作用，塑造肾上腺和睾丸以产生生存所需的激素。在包括自身免疫性疾病在内的特定病理情况下，精液中含有高水平的细胞因子，这些细胞因子在调节男性性腺的免疫功能方面起着至关重要的作用。本综述重点探讨了细胞因子在男性生殖调控和发育中的免疫作用，以及在维持男性生殖健康和与睾丸中功能异常相关的疾病中的作用。
