Department of Gastroenterology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, Hubei Province, China.
Department of Gastroenterology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, Hubei Province, China.
Int Immunopharmacol. 2023 Sep;122:110576. doi: 10.1016/j.intimp.2023.110576. Epub 2023 Jun 28.
Many researches have reported the impairment of regulatory T cells (Tregs) in autoimmune hepatitis (AIH), whilst the change of Tregs in peripheral blood remains controversial. We performed this systematic review and meta-analysis to clarify the numerical change of circulating Tregs in AIH patients compared with healthy individuals.
Relevant studies were identified from Medline, PubMed, Embase, Web of Science, the Cochrane Library, China National Knowledge Infrastructure, and WanFang Data. Twenty-nine studies involving 968 AIH patients and 583 healthy controls were included. Subgroup analysis stratified by Treg definition or ethnicity was performed, and analysis of active-phase AIH was conducted.
The proportions of Tregs among CD4 T cells and PBMCs were generally decreased in AIH patients compared with healthy controls. Subgroup analysis showed that circulating Tregs identified by CD4CD25, CD4CD25Foxp3, CD4CD25CD127, and Tregs in Asian population were decreased among CD4 T cells in AIH patients. No significant change of CD4CD25Foxp3CD127 Tregs and Tregs in Caucasian population among CD4 T cells were found in AIH patients, whereas the number of studies was limited in these subgroups. Moreover, analysis of the active-phase AIH patients showed that Treg proportions were decreased generally, whereas no significant differences in Tregs/CD4 T cells were observed when markers CD4CD25Foxp3, CD4CD25Foxp3CD127 were used or in Caucasian population.
The proportions of Tregs among CD4 T cells and PBMCs were decreased in AIH patients compared with healthy controls generally, whereas Treg definition markers, ethnicity, and disease activity had influence on the results. Further large-scale and rigorous study is warranted.
许多研究报告称，自身免疫性肝炎（AIH）患者的调节性 T 细胞（Tregs）受损，而外周血 Tregs 的变化仍存在争议。我们进行了这项系统评价和荟萃分析，以明确与健康个体相比，AIH 患者循环 Tregs 的数量变化。
从 Medline、PubMed、Embase、Web of Science、Cochrane 图书馆、中国国家知识基础设施和万方数据中检索相关研究。共纳入 29 项研究，涉及 968 例 AIH 患者和 583 例健康对照者。进行了 Treg 定义或种族的亚组分析，并对活动期 AIH 进行了分析。
与健康对照组相比，AIH 患者 CD4 T 细胞和 PBMC 中的 Treg 比例普遍降低。亚组分析显示，AIH 患者 CD4 T 细胞中以 CD4CD25、CD4CD25Foxp3、CD4CD25CD127 和 Tregs 定义的循环 Tregs 减少，以 CD4CD25Foxp3CD127 Tregs 和白人人群中的 Tregs 定义的循环 Tregs 减少。在 AIH 患者中，未发现 CD4CD25Foxp3 Tregs 和以 CD4CD25Foxp3CD127 Tregs 和白人人群中 Tregs 定义的循环 Tregs 比例的显著变化，但是这些亚组的研究数量有限。此外，对活动期 AIH 患者的分析显示，Treg 比例普遍降低，而当使用 CD4CD25Foxp3、CD4CD25Foxp3CD127 等标志物或在白人人群中时，Tregs/CD4 T 细胞无显著差异。
与健康对照组相比，AIH 患者 CD4 T 细胞和 PBMC 中的 Treg 比例普遍降低，而 Treg 定义标志物、种族和疾病活动度对结果有影响。需要进一步进行大规模和严格的研究。
