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自身免疫性肝炎的治疗进展

Advances in the Treatment of Autoimmune Hepatitis.

作者信息

Meng Zelu, Yang Yida

机构信息

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, National Medical Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.

出版信息

J Clin Transl Hepatol. 2024 Oct 28;12(10):878-885. doi: 10.14218/JCTH.2024.00193. Epub 2024 Sep 24.

DOI:10.14218/JCTH.2024.00193
PMID:39440223
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11491506/
Abstract

Autoimmune hepatitis (AIH) is a chronic, progressive inflammatory liver disease caused by autoimmune reactions, with an unknown etiology. If left untreated, it can progress to cirrhosis, liver failure, or even death. While most patients respond well to first-line treatments, a significant number experience poor responses or intolerance, requiring the use of second- or third-line therapies. Ongoing research into the pathogenesis of AIH is leading to the development of novel therapeutic approaches. This review summarized recent advancements in the treatment of AIH both domestically and internationally.

摘要

自身免疫性肝炎（AIH）是一种由自身免疫反应引起的慢性进行性炎症性肝病，病因不明。如果不进行治疗，它可能会发展为肝硬化、肝衰竭，甚至死亡。虽然大多数患者对一线治疗反应良好，但仍有相当一部分患者反应不佳或不耐受，需要使用二线或三线疗法。对AIH发病机制的持续研究正在推动新型治疗方法的开发。这篇综述总结了国内外AIH治疗的最新进展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bb6/11491506/14d779adee41/JCTH-12-878-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bb6/11491506/14d779adee41/JCTH-12-878-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bb6/11491506/14d779adee41/JCTH-12-878-g001.jpg

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Real-world evidence for factors associated with maintenance treatment practices among US adults with autoimmune hepatitis.美国自身免疫性肝炎成年患者维持治疗实践相关因素的真实世界证据。
Hepatology. 2025 Feb 1;81(2):423-435. doi: 10.1097/HEP.0000000000000961. Epub 2024 Jun 12.
2
Genomic testing for inborn errors of immunity in seronegative autoimmune hepatitis of childhood.儿童血清阴性自身免疫性肝炎中免疫缺陷病的基因检测
J Hepatol. 2024 Oct;81(4):e151-e152. doi: 10.1016/j.jhep.2024.04.021. Epub 2024 Apr 26.
3
JAK Inhibition in STAT1 Gain-of-Function-Mediated Treatment-Resistant Autoimmune Hepatitis.
JAK抑制在STAT1功能获得性介导的难治性自身免疫性肝炎中的作用
N Engl J Med. 2024 Jan 18;390(3):284-286. doi: 10.1056/NEJMc2311867.
4
An open-label randomised-controlled trial of azathioprine vs. mycophenolate mofetil for the induction of remission in treatment-naive autoimmune hepatitis.一项在初治自身免疫性肝炎患者中比较硫唑嘌呤与霉酚酸酯诱导缓解作用的开放性随机对照临床试验。
J Hepatol. 2024 Apr;80(4):576-585. doi: 10.1016/j.jhep.2023.11.032. Epub 2023 Dec 14.
5
Therapeutic Phages as Modulators of the Immune Response: Practical Implications.治疗性噬菌体作为免疫反应调节剂：实际意义。
Clin Infect Dis. 2023 Nov 2;77(Suppl 5):S433-S439. doi: 10.1093/cid/ciad483.
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Fecal microbiota transplantation regulates TFH/TFR cell imbalance via TLR/MyD88 pathway in experimental autoimmune hepatitis.粪便微生物群移植通过TLR/MyD88途径调节实验性自身免疫性肝炎中的TFH/TFR细胞失衡。
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J Hepatol. 2024 Jan;80(1):e26-e28. doi: 10.1016/j.jhep.2023.09.028. Epub 2023 Oct 17.
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J Autoimmun. 2023 Nov;140:103113. doi: 10.1016/j.jaut.2023.103113. Epub 2023 Sep 15.
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Int Immunopharmacol. 2023 Sep;122:110576. doi: 10.1016/j.intimp.2023.110576. Epub 2023 Jun 28.
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Long-term outcome of liver transplantation for autoimmune hepatitis: A French nationwide study over 30 years.自身免疫性肝炎肝移植的长期预后：一项法国全国性30年研究。
Liver Int. 2023 May;43(5):1068-1079. doi: 10.1111/liv.15552. Epub 2023 Mar 8.