Meng Zelu, Yang Yida
State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, National Medical Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
J Clin Transl Hepatol. 2024 Oct 28;12(10):878-885. doi: 10.14218/JCTH.2024.00193. Epub 2024 Sep 24.
Autoimmune hepatitis (AIH) is a chronic, progressive inflammatory liver disease caused by autoimmune reactions, with an unknown etiology. If left untreated, it can progress to cirrhosis, liver failure, or even death. While most patients respond well to first-line treatments, a significant number experience poor responses or intolerance, requiring the use of second- or third-line therapies. Ongoing research into the pathogenesis of AIH is leading to the development of novel therapeutic approaches. This review summarized recent advancements in the treatment of AIH both domestically and internationally.
自身免疫性肝炎(AIH)是一种由自身免疫反应引起的慢性进行性炎症性肝病,病因不明。如果不进行治疗,它可能会发展为肝硬化、肝衰竭,甚至死亡。虽然大多数患者对一线治疗反应良好,但仍有相当一部分患者反应不佳或不耐受,需要使用二线或三线疗法。对AIH发病机制的持续研究正在推动新型治疗方法的开发。这篇综述总结了国内外AIH治疗的最新进展。