Clinical Medical College, Yangzhou University, Yangzhou, Jiangsu Province 225000, China.
Department of General Surgery, Institute of General Surgery, Clinical Medical College, Yangzhou University, Northern Jiangsu People's Hospital, Yangzhou 225000, China.
Int Immunopharmacol. 2023 Sep;122:110492. doi: 10.1016/j.intimp.2023.110492. Epub 2023 Jun 28.
Heat shock protein 70 (HSP70) is a highly conserved protein composed of nucleotide-binding domains (NBD) and C-terminal substrate binding domain (SBD) that can function as a "molecular chaperone". HSP70 was discovered to directly or indirectly play a regulatory role in both internal and external apoptosis pathways. Studies have shown that HSP70 can not only promote tumor progression, enhance tumor cell resistance and inhibit anticancer effects but also induce an anticancer response by activating immune cells. In addition, chemotherapy, radiotherapy and immunotherapy for cancer may be affected by HSP70, which has shown promising potential as an anticancer drug. In this review, we summarized the molecular structure and mechanism of HSP70 and discussed the dual effects of HSP70 on tumor cells and the possibility and potential methods of using HSP70 as a target to treat cancer.
热休克蛋白 70（HSP70）是一种高度保守的蛋白质，由核苷酸结合域（NBD）和 C 端底物结合域（SBD）组成，可作为“分子伴侣”发挥作用。HSP70 被发现直接或间接在内外凋亡途径中发挥调节作用。研究表明，HSP70 不仅可以促进肿瘤进展，增强肿瘤细胞耐药性并抑制抗癌作用，还可以通过激活免疫细胞诱导抗癌反应。此外，癌症的化疗、放疗和免疫治疗可能受 HSP70 的影响，HSP70 作为抗癌药物具有很大的应用潜力。在本文中，我们总结了 HSP70 的分子结构和机制，并讨论了 HSP70 对肿瘤细胞的双重作用以及将 HSP70 作为治疗癌症的靶点的可能性和潜在方法。
