Vostakolaei Mehdi Asghari, Abdolalizadeh Jalal, Hejazi Mohammad Saeid, Kordi Shirafkan, Molavi Ommoleila
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran AND Department of Pharmaceutical Biotechnology, Faculty of pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran AND Paramedical Faculty, Tabriz University of Medical Sciences, Tabriz, Iran.
Iran J Allergy Asthma Immunol. 2019 Dec 4;18(6):589-604. doi: 10.18502/ijaai.v18i6.2172.
Heat shock protein 70.1 (Hsp70.1), also known as Hsp70, is a highly conserved member of the heat shock protein family that exists in all living organisms and determines the protein fate as molecular chaperones. Hsp70 basal expression is undetectable or low in most unstressed normal cells, however, its abundant presence in several types of human cancer cells is reported. Several studies support upregulated Hsp70 involved in tumor progression and drug resistance through modulation of cell death pathways and suppresses anticancer immune responses. However, numerous studies have confirmed that Hsp70 can also induce anticancer immune responses through the activation of immune cells in particular antigen-presenting cells (APCs). Regarding the significant and the promising role of vaccines in cancer immunotherapy, identification and characterization of the overexpressed Hsp70 as a potential immune stimulatory factor can pave the path for development of highly effective anticancer vaccines. In this review, we will discuss the interactions of Hsp70 with components of the immune system in cancers as well as possible strategies to harness Hsp70 for eliciting anticancer immune responses.
热休克蛋白70.1（Hsp70.1），也被称为Hsp70，是热休克蛋白家族中高度保守的成员，存在于所有生物体内，并作为分子伴侣决定蛋白质的命运。在大多数未受应激的正常细胞中，Hsp70的基础表达无法检测到或水平较低，然而，据报道其在几种人类癌细胞中大量存在。多项研究表明，上调的Hsp70通过调节细胞死亡途径参与肿瘤进展和耐药性，并抑制抗癌免疫反应。然而，大量研究证实，Hsp70也可通过激活免疫细胞尤其是抗原呈递细胞（APC）来诱导抗癌免疫反应。鉴于疫苗在癌症免疫治疗中的重要且有前景的作用，将过表达的Hsp70鉴定和表征为潜在的免疫刺激因子可为开发高效抗癌疫苗铺平道路。在本综述中，我们将讨论癌症中Hsp70与免疫系统成分的相互作用，以及利用Hsp70引发抗癌免疫反应的可能策略。
