School of Physics, Universiti Sains Malaysia, 11800 Gelugor, Penang, Malaysia.
Advanced Medical and Dental Institute, Universiti Sains Malaysia, Bertam, 13200 Kepala Batas, Penang, Malaysia.
Colloids Surf B Biointerfaces. 2023 Aug;228:113423. doi: 10.1016/j.colsurfb.2023.113423. Epub 2023 Jun 20.
The novelty of this work is the conjugation of poly(ethylene) oxide (PEO) with the erbium oxide (ErO) nanoparticles using the electrospinning technique. In this work, synthesised PEO-coated ErO nanofibres were characterised and evaluated for their cytotoxicity to assess their potential use as diagnostic nanofibres for magnetic resonance imaging (MRI). PEO has significantly impacted nanoparticle conductivity due to its lower ionic conductivity at room temperature. The findings showed that the surface roughness was improved over the nanofiller loading, implying an improvement in cell attachment. The release profile performed for drug-controlling purposes has demonstrated a stable release after 30 min. Cellular response in MCF-7 cells showed high biocompatibility of the synthesised nanofibres. The cytotoxicity assay results showed that the diagnostic nanofibres had excellent biocompatibility, indicating the feasibility for diagnosis purposes. With excellent contrast performance, the PEO-coated ErO nanofibres developed novel T and T-T dual-mode MRI diagnostic nanofibres leading to better cancer diagnosis. In conclusion, this work has demonstrated that the conjugation of PEO-coated ErO nanofibres improved the surface modification of the ErO nanoparticles as a potential diagnostic agent. Using PEO in this study as a carrier or polymer matrix significantly influenced the biocompatibility and internalisation efficiency of the ErO nanoparticles without triggering any morphological changes after treatment. This work has suggested permissible concentrations of PEO-coated ErO nanofibres for diagnostic uses.
这项工作的新颖之处在于使用静电纺丝技术将聚氧化乙烯（PEO）与氧化铒（ErO）纳米颗粒结合。在这项工作中，合成的 PEO 包覆的 ErO 纳米纤维进行了表征，并对其细胞毒性进行了评估，以评估其作为磁共振成像（MRI）诊断纳米纤维的潜力。PEO 的离子电导率在室温下较低，显著影响了纳米颗粒的导电性。研究结果表明，随着纳米填料负载量的增加，表面粗糙度得到了改善，这意味着细胞附着得到了改善。为了控制药物释放而进行的释放曲线表明，在 30 分钟后实现了稳定释放。MCF-7 细胞的细胞反应表明，所合成的纳米纤维具有很高的生物相容性。细胞毒性测定结果表明，诊断用纳米纤维具有优异的生物相容性，表明其适用于诊断目的。具有出色的对比性能，PEO 包覆的 ErO 纳米纤维开发出新型 T 和 T-T 双模 MRI 诊断纳米纤维，从而实现更好的癌症诊断。总之，这项工作表明，PEO 包覆的 ErO 纳米纤维的结合改善了 ErO 纳米颗粒的表面修饰，作为一种潜在的诊断剂。在本研究中，使用 PEO 作为载体或聚合物基质，在不引发任何形态变化的情况下，显著影响了 ErO 纳米颗粒的生物相容性和内化效率。这项工作建议了用于诊断用途的 PEO 包覆的 ErO 纳米纤维的允许浓度。
