Friedman M A, Sadée W
Cancer Chemother Pharmacol. 1978;1(2):77-82. doi: 10.1007/BF00254040.
Our understanding of the biochemical events of fluoropyrimidine-induced cytotoxicity remains incomplete. However, we have a good perception of the activation and degradation pathways of these agents. Additionally, from studies performed in vitro we are gaining a new appreciation of the interactions between methotrexate and the fluoropyrimidines. These studies suggest that the common clinical practice of simultaneously administering methotrexate and 5-fluorouracil may be disadvantageous. Several simple scheduling modifications of combination therapies with these two drugs could lead to improved clinical efficacy and deserve further investigation.
我们对氟嘧啶诱导细胞毒性的生化事件的理解仍不完整。然而，我们对这些药物的激活和降解途径有了较好的认识。此外，通过体外研究，我们对甲氨蝶呤与氟嘧啶之间的相互作用有了新的认识。这些研究表明，同时给予甲氨蝶呤和5-氟尿嘧啶的常见临床做法可能是不利的。对这两种药物联合治疗进行一些简单的给药方案调整可能会提高临床疗效，值得进一步研究。
