Townsend Leigh T J, Anderson Kirstie N, Boeve Bradley F, McKeith Ian, Taylor John-Paul
Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK.
Cumbria, Northumberland, Tyne and Wear NHS Foundation Trust, Newcastle upon Tyne, UK.
Alzheimers Dement. 2023 Nov;19(11):5264-5283. doi: 10.1002/alz.13350. Epub 2023 Jul 1.
In Lewy body dementia (LBD), disturbances of sleep and/or arousal including insomnia, excessive daytime sleepiness, rapid eye movement (REM) sleep behavior disorder, obstructive sleep apnea, and restless leg syndrome are common. These disorders can each exert a significant negative impact on both patient and caregiver quality of life; however, their etiology is poorly understood. Little guidance is available for assessing and managing sleep disorders in LBD, and they remain under-diagnosed and under-treated. This review aims to (1) describe the specific sleep disorders which occur in LBD, considering their putative or potential mechanisms; (2) describe the history and diagnostic process for these disorders in LBD; and (3) summarize current evidence for their management in LBD and consider some of the ongoing and unanswered questions in this field and future research directions.
在路易体痴呆（LBD）中，睡眠和/或觉醒障碍很常见，包括失眠、日间过度嗜睡、快速眼动（REM）睡眠行为障碍、阻塞性睡眠呼吸暂停和不宁腿综合征。这些障碍会对患者和照料者的生活质量产生重大负面影响；然而，其病因尚不清楚。在评估和管理LBD中的睡眠障碍方面几乎没有指导意见，这些障碍仍然诊断不足且治疗不足。本综述旨在：（1）描述LBD中出现的特定睡眠障碍，同时考虑其假定或潜在机制；（2）描述LBD中这些障碍的病史和诊断过程；（3）总结目前LBD中对其管理的证据，并考虑该领域一些尚未解决的问题以及未来的研究方向。
