van Norren D, Heynen H
Vision Res. 1986;26(4):569-75. doi: 10.1016/0042-6989(86)90005-2.
To investigate the origin of the fast oscillation, a phenomenon in the electroretinogram evoked with stimulus frequencies of about 8 mHz (a period time of about 2 min), we recorded responses from retina and pigment epithelium in the macaque. Micropipettes were placed in the subretinal space and in the vitreous close to the retina; the reference electrode was in the orbit behind the eye. Thus, simultaneous recordings were obtained of the trans-epithelial, the trans-retinal and the trans-tissue (vitreal) potential. At 10 mHz the trans-retinal and the trans-epithelial responses are of about equal magnitude but of opposite phase, resulting in a small and rather variable vitreal potential. The origin of the fast oscillation evoked with repetitive stimuli lies in subtle differences between retinal and pigment epithelial potentials, in which a pigment epithelial event plays an important role. For single stimuli lasting 60 s again the trans-epithelial and trans-retinal responses were of equal magnitude and opposite polarity. The epithelial responses were found to return more quickly towards the baseline than the retinal responses. In vitreal recordings this causes a trough between the c-wave and the light peak which is referred to as the "trough" fast oscillation. Most of the "trough" fast oscillation is caused by a pigment epithelial event. In view of the complexity of the fast oscillation evoked with repetitive stimuli it might be difficult to relate pathology to specific neuro-epithelial structures.
为了研究快速振荡的起源，这是一种在以约8毫赫兹（约2分钟的周期时间）的刺激频率诱发的视网膜电图中的现象，我们记录了猕猴视网膜和色素上皮的反应。微电极置于视网膜下间隙和靠近视网膜的玻璃体中；参考电极置于眼后的眼眶内。因此，同时记录了跨上皮、跨视网膜和跨组织（玻璃体）电位。在10毫赫兹时，跨视网膜和跨上皮反应幅度大致相等，但相位相反，导致玻璃体电位较小且变化较大。重复刺激诱发的快速振荡的起源在于视网膜和色素上皮电位之间的细微差异，其中色素上皮事件起着重要作用。对于持续60秒的单个刺激，跨上皮和跨视网膜反应同样幅度相等、极性相反。发现上皮反应比视网膜反应更快地回到基线。在玻璃体记录中，这会在c波和光峰之间产生一个波谷，称为“波谷”快速振荡。大部分“波谷”快速振荡是由色素上皮事件引起的。鉴于重复刺激诱发的快速振荡的复杂性，可能难以将病理学与特定的神经上皮结构联系起来。
