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酰基化和疾病:当前的进展和未来展望。

Crotonylation and disease: Current progress and future perspectives.

机构信息

Department of Nephrology, The Affiliated Hospital of Southwest Medical University, Luzhou 646000 Sichuan, China; Metabolic Vascular Disease Key Laboratory of Sichuan Province, The Affiliated Hospital of Southwest Medical University, Luzhou 646000 Sichuan, China; Sichuan Clinical Research Center for Nephropathy, Luzhou 646000 Sichuan, China.

Department of Nephrology, The Affiliated Hospital of Southwest Medical University, Luzhou 646000 Sichuan, China.

出版信息

Biomed Pharmacother. 2023 Sep;165:115108. doi: 10.1016/j.biopha.2023.115108. Epub 2023 Jun 29.

Abstract

Histone lysine crotonylation was first identified as a new type of post-translational modification in 2011. In recent years, prominent progress has been made in the study of histone and nonhistone crotonylation in reproduction, development, and disease. Although the regulatory enzyme systems and targets of crotonylation partially overlap with those of acetylation, the peculiar CC bond structure of crotonylation suggests that crotonylation may have specific biological functions. In this review, we summarize the latest research progress regarding crotonylation, especially its regulatory factors and relationship with diseases, which suggest further research directions for crotonylation and provide new ideas for developing disease intervention and treatment regimens.

摘要

组蛋白赖氨酸巴豆酰化于 2011 年首次被鉴定为一种新型的翻译后修饰。近年来,在生殖、发育和疾病中组蛋白和非组蛋白巴豆酰化的研究取得了显著进展。尽管巴豆酰化的调控酶系统和靶标部分与乙酰化重叠,但巴豆酰化独特的 CC 键结构表明,巴豆酰化可能具有特定的生物学功能。在这篇综述中,我们总结了巴豆酰化的最新研究进展,特别是其调控因子与疾病的关系,为巴豆酰化的进一步研究提供了方向,并为开发疾病干预和治疗方案提供了新思路。

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