Department of Nuclear Medicine, The First Affiliated Hospital of Shandong First Medical University, Jinan, 250014, China.
Medical Research Center, The First Affiliated Hospital of Shandong First Medical University, Jinan, 250014, China.
Epigenetics Chromatin. 2021 Feb 6;14(1):10. doi: 10.1186/s13072-021-00385-9.
Histone crotonylation is a recently described post-translational modification that occurs at multiple identified histone lysine crotonylation sites. An increasing number of studies have demonstrated that histone crotonylation at DNA regulatory elements plays an important role in the activation of gene transcription. However, among others, we have shown that elevated cellular crotonylation levels result in the inhibition of endocytosis-related gene expression and pro-growth gene expression, implicating the complexity of histone crotonylation in gene regulation. Therefore, it is important to understand how histone crotonylation is regulated and how it, in turn, regulates the expression of its target genes. In this review, we summarize the regulatory factors that control histone crotonylation and discuss the role of different histone crotonylation sites in regulating gene expression, while providing novel insights into the central role of histone crotonylation in gene regulation.
组蛋白巴豆酰化是一种新近描述的翻译后修饰，发生在多个已鉴定的组蛋白赖氨酸巴豆酰化位点上。越来越多的研究表明，DNA 调节元件上的组蛋白巴豆酰化在基因转录的激活中起着重要作用。然而，我们已经表明，细胞内巴豆酰化水平的升高导致内吞相关基因表达和促生长基因表达的抑制，这表明组蛋白巴豆酰化在基因调控中的复杂性。因此，了解组蛋白巴豆酰化如何被调控以及它如何反过来调控其靶基因的表达是很重要的。在这篇综述中，我们总结了控制组蛋白巴豆酰化的调节因子，并讨论了不同组蛋白巴豆酰化位点在调节基因表达中的作用，同时为组蛋白巴豆酰化在基因调控中的核心作用提供了新的见解。
