Department of Dermatology, University of Utah, 30 North 1900 East, 4A330, Salt Lake City, UT 84132, USA; Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope Drive, Salt Lake City, UT 84112, USA.
Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope Drive, Salt Lake City, UT 84112, USA.
Contemp Clin Trials. 2023 Aug;131:107276. doi: 10.1016/j.cct.2023.107276. Epub 2023 Jun 29.
Children of parents who had melanoma are more likely to develop skin cancer themselves owing to shared familial risks. The prevention of sunburns and promotion of sun-protective behaviors are essential to control cancer among these children. The Family Lifestyles, Actions and Risk Education (FLARE) intervention will be delivered as part of a randomized controlled trial to support parent-child collaboration to improve sun safety outcomes among children of melanoma survivors.
FLARE is a two-arm randomized controlled trial design that will recruit dyads comprised of a parent who is a melanoma survivor and their child (aged 8-17 years). Dyads will be randomized to receive FLARE or standard skin cancer prevention education, which both entail 3 telehealth sessions with an interventionist. FLARE is guided by Social-Cognitive and Protection Motivation theories to target child sun protection behaviors through parent and child perceived risk for melanoma, problem-solving skills, and development of a family skin protection action plan to promote positive modeling of sun protection behaviors. At multiple assessments through one-year post-baseline, parents and children complete surveys to assess frequency of reported child sunburns, child sun protection behaviors and melanin-induced surface skin color change, and potential mediators of intervention effects (e.g., parent-child modeling).
The FLARE trial addresses the need for melanoma preventive interventions for children with familial risk for the disease. If efficacious, FLARE could help to mitigate familial risk for melanoma among these children by teaching practices which, if enacted, decrease sunburn occurrence and improve children's use of well-established sun protection strategies.
由于存在家族风险,父母一方患有黑色素瘤的儿童自身更有可能患上皮肤癌。预防晒伤和促进防晒行为对于控制这些儿童的癌症至关重要。“家庭生活方式、行动和风险教育(FLARE)”干预措施将作为一项随机对照试验的一部分提供,以支持父母与子女合作,改善黑色素瘤幸存者子女的防晒安全结果。
FLARE 是一项两臂随机对照试验设计,将招募由黑色素瘤幸存者父母及其子女(8-17 岁)组成的对子。对子将随机接受 FLARE 或标准皮肤癌预防教育,两者都需要与干预者进行 3 次远程健康会话。FLARE 以社会认知和保护动机理论为指导,通过父母和儿童对黑色素瘤风险的感知、解决问题的技能,以及制定家庭皮肤保护行动计划,针对儿童的防晒行为,以促进防晒行为的积极示范。在基线后一年的多次评估中,父母和子女完成调查,以评估报告的儿童晒伤频率、儿童防晒行为和黑色素诱导的表面皮肤颜色变化,以及干预效果的潜在中介因素(例如,父母-子女示范)。
FLARE 试验满足了针对具有疾病家族风险的儿童进行黑色素瘤预防干预的需求。如果有效,FLARE 可以通过教授实践来减轻这些儿童的黑色素瘤家族风险,如果实施,这些实践可以减少晒伤的发生,并改善儿童对既定防晒策略的使用。