Nakayama T
Yale J Biol Med. 1986 Mar-Apr;59(2):189-95.
The hypothalamic thermoregulatory center was regarded as a black box some 20 years ago. Subsequent microelectrode exploration revealed the existence of two kinds of thermosensitive neurons in this area. Discharges of these neurons are now recorded not only from anesthetized animals but also from tissue explants, tissue slices, and unanesthetized animals as well. Neuronal responses produced by some stimuli have been compared to whole-body thermoregulatory responses. Parallelism between the two was found in the actions of chemicals, in integration of peripheral and central temperatures, in cortical influence, and in temperature effects on other hypothalamic functions, implicating specific key roles to thermosensitive neurons in thermoregulation.
大约20年前，下丘脑体温调节中枢被视为一个黑箱。随后的微电极探测揭示了该区域存在两种热敏神经元。现在不仅从麻醉动物，而且也从组织外植体、组织切片和未麻醉动物中记录这些神经元的放电。已将某些刺激产生的神经元反应与全身体温调节反应进行了比较。在化学物质的作用、外周和中枢温度的整合、皮层影响以及温度对其他下丘脑功能的作用方面，发现两者之间存在平行关系，这意味着热敏神经元在体温调节中具有特定的关键作用。
