Glotzbach S F, Heller H C
Brain Res. 1984 Aug 20;309(1):17-26. doi: 10.1016/0006-8993(84)91006-0.
The characteristics of the mammalian thermoregulatory system are dependent upon arousal state. During NREM sleep thermoregulatory mechanisms are intact but body temperature is regulated at a lower level than during wakefulness. In REM sleep thermoregulatory effector mechanisms are inhibited and thermal homeostasis is severely disrupted. Thermosensitivity of neurons in the preoptic/anterior hypothalamus (POAH) was determined for behaving kangaroo rats (Dipodomys deserti) during electrophysiologically defined wakefulness, NREM sleep and REM sleep to elucidate possible neural mechanisms for previous findings of state-dependent changes in thermoregulation. Thirty cells were tested during at least two arousal states. During wakefulness, 70% of the recorded cells were sensitive to changes in local temperature, with the number of warm-sensitive (W) cells outnumbering cold-sensitive (C) cells by 1.6:1. In NREM sleep, 43% of the cells were thermally sensitive, with the ratio of W:C remaining the same as in wakefulness. In REM sleep only two cells were thermosensitive (both W). The decrease in neuronal thermosensitivity of POAH cells during REM sleep parallels findings of inhibition of thermoregulatory effector responses during REM, although further work is necessary to determine the source and nature of the inhibition.
哺乳动物体温调节系统的特征取决于觉醒状态。在非快速眼动睡眠期间，体温调节机制完好无损，但体温被调节在比清醒时更低的水平。在快速眼动睡眠中，体温调节效应机制受到抑制，热稳态受到严重破坏。为了阐明先前关于体温调节中状态依赖性变化的研究结果的可能神经机制，对行为活跃的更格卢鼠（荒漠更格卢鼠）在电生理定义的清醒、非快速眼动睡眠和快速眼动睡眠期间视前区/下丘脑前部（POAH）神经元的热敏性进行了测定。在至少两种觉醒状态下对30个细胞进行了测试。在清醒期间，70%的记录细胞对局部温度变化敏感，热敏（W）细胞数量比冷敏（C）细胞多1.6:1。在非快速眼动睡眠中，43%的细胞对热敏感，W:C的比例与清醒时相同。在快速眼动睡眠中，只有两个细胞对热敏感（均为W）。快速眼动睡眠期间POAH细胞神经元热敏性的降低与快速眼动期间体温调节效应反应受到抑制的研究结果相似，尽管需要进一步的研究来确定抑制的来源和性质。
