Operative Dentistry & Endodontics, Aga Khan University Hospital, Karachi, Pakistan.
Department of Surgery, Aga Khan University Hospital, Karachi, Pakistan.
BMC Oral Health. 2023 Jul 2;23(1):441. doi: 10.1186/s12903-023-03128-2.
Deep-seated fungal infections of the oral cavity present a diagnostic challenge as the clinical presentation is usually aggressive leading to misdiagnosis of malignancy. Nevertheless, the species of fungi responsible for such diseases in immunocompromised individuals are varied thus, further complicating the diagnosis.
Presented below is a case regarding the diagnosis and management of deep mycotic infection of the oral cavity caused by a fungus that very rarely causes disease in humans, the Verticillium species.
The case highlights the fact that rare pathogens should also be considered in the differential diagnosis, especially in patients with debilitating conditions like uncontrolled diabetes. Likewise, histopathological evaluation and microbiological investigations are of paramount importance and remain the gold standard to reach a definitive diagnosis.
深部真菌感染口腔会带来诊断上的挑战,因为其临床表现通常很具侵袭性,导致恶性肿瘤的误诊。然而,在免疫功能低下个体中导致此类疾病的真菌种类繁多,这进一步使诊断复杂化。
下面介绍了一例由一种在人类中很少引起疾病的真菌——Verticillium 属引起的深部口腔真菌病的诊断和治疗。
该病例强调了一个事实,即即使是罕见的病原体也应在鉴别诊断中加以考虑,尤其是在患有衰弱性疾病(如未控制的糖尿病)的患者中。同样,组织病理学评估和微生物学研究非常重要,仍然是做出明确诊断的金标准。