Meier P
Clin Pharmacol Ther. 1979 May;25(5 Pt 2):633-40. doi: 10.1002/cpt1979255part2633.
A comparative clinical trial will often lead to the conclusion that one regimen is clearly better than another. Should the estimated difference in the regimens be large and precisely determined, continuation of the trial would constitute abuse of the participants. Some earlier proposals for ethical decision making on continuing a trial are shown to be unsatisfactory, and a more general framework for dealing with the problem is proposed.
一种治疗方案明显优于另一种。如果两种方案之间估计的差异很大且已精确确定，继续进行试验将构成对受试者的伤害。事实证明，一些早期关于继续试验的伦理决策提议并不令人满意，因此本文提出了一个更通用的框架来处理该问题。
