Müller G, Heilmann P
Zentralbl Bakteriol Mikrobiol Hyg A. 1986 May;261(3):370-80.
Model experiments with mice are presented in which the defense against challenge infections has been checked after immunization with various living and killed vaccines of Pasteurella. A temperature sensitive Pasteurella mutant has proved to be superior to inactivated bacteria. It has been established that different routes of administration result in different effects. In this context, intraperitoneal, intramuscular and intratracheal administration have resulted in the highest protection rates, even when combined with oral and aerogeneous immunizations, which are of little efficacy when used exclusively. The importance of a change in the route of administration during repeated immunizations is discussed.
本文展示了用小鼠进行的模型实验，其中在用各种活的和灭活的巴氏杆菌疫苗免疫后，检测了对激发感染的防御能力。一种温度敏感的巴氏杆菌突变体已被证明优于灭活细菌。已经确定不同的给药途径会产生不同的效果。在这种情况下，腹腔内、肌肉内和气管内给药产生了最高的保护率，即使与口服和气溶胶免疫联合使用时也是如此，而单独使用口服和气溶胶免疫时效果甚微。讨论了在重复免疫期间改变给药途径的重要性。
