Division of Neonatology, Department of Pediatrics, Sariyer Hamidiye Etfal Education and Research Hospital, Istanbul, Turkey.
Division of Neonatology, Ankara Education and Research Hospital, Ankara, Turkey.
J Matern Fetal Neonatal Med. 2023 Dec;36(2):2231121. doi: 10.1080/14767058.2023.2231121.
To investigate the weight gain pattern of preterm infants with bronchopulmonary dysplasia (BPD) during the hospital stay using weekly weight assessment methods.
This single-center, retrospective, cohort study was carried out in Zekai Tahir Burak Maternal Health Education and Research Hospital between 2014 and 2018. One hundred fifty-one preterm infants <32 weeks of gestation and <1500 g of birth weight with BPD were compared to 251 babies without BPD in terms of weekly weight gain, standard deviation score (SDS), and fall in weight SDS till discharge.
Mean body weight was significantly lower in babies with BPD in all weeks except postnatal week (PW) 8. The groups had similar daily weight gain between birth and discharge ( = .78). Infants with BPD had lower weight SDS on postnatal day (PD) 14 and 21, and discharge, however similar on PD 28. The fall in SDS between PW 4 and discharge was significantly higher in the BPD group. Infants with BPD had higher fall in weight SDS between birth and discharge ( = .022). Discharge weight SDS was associated with gestational age and weight SDS on PW 4 in the whole cohort.
Infants with BPD showed a unique and unsteady pattern of growth compromise during the NICU course, most explicitly in early postnatal life and between PD 28-discharge. Future studies should consider not only the early postnatal life but also the period after four weeks of life till discharge to design an optimal nutrition strategy and decent growth for preterm infants with BPD.
使用每周体重评估方法，研究患有支气管肺发育不良（BPD）的早产儿在住院期间的体重增长模式。
这项单中心、回顾性队列研究于 2014 年至 2018 年在泽凯·塔希尔·布拉卡母婴健康教育培训与研究医院进行。将 151 名胎龄<32 周且出生体重<1500g 的患有 BPD 的早产儿与 251 名无 BPD 的婴儿进行比较，比较内容为每周体重增加量、标准偏差评分（SDS）和直至出院时体重 SDS 的下降情况。
除出生后第 8 周外，患有 BPD 的婴儿在所有周的平均体重均明显较低。两组在出生至出院期间的每日体重增加量相似（ = .78）。患有 BPD 的婴儿在出生后第 14 天和第 21 天以及出院时的体重 SDS 较低，但在第 28 天相似。BPD 组在第 4 周至出院期间 SDS 的下降幅度明显较高。出生至出院期间，体重 SDS 的下降幅度在患有 BPD 的婴儿中较高（ = .022）。在整个队列中，出院时的体重 SDS 与胎龄和第 4 周时的体重 SDS 相关。
患有 BPD 的婴儿在新生儿重症监护病房（NICU）期间的生长受到了独特且不稳定的影响，在早期新生儿期和第 28 天至出院期间最为明显。未来的研究应考虑不仅是早期新生儿期，还应考虑四周后至出院期间，以便为患有 BPD 的早产儿设计最佳的营养策略和良好的生长方案。
