Department of Veterinary & Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, Twin Cities, MN, USA.
Virulence. 2023 Dec;14(1):2231392. doi: 10.1080/21505594.2023.2231392.
Mammarenaviruses, a genus of the family , are capable of infecting mammals and are primarily found in rodent reservoirs worldwide. Mammarenaviruses can be transmitted to humans through contact with infected rodents, and though infection is often asymptomatic, some members of this genus can cause viral haemorrhagic fever which has mortality rates ranging from 1% to 50%. These viruses are typically restricted geographically, based on the geographical range of their host reservoirs. Lymphocytic choriomeningitis virus (LCMV) was previously thought to be the only mammarenavirus found across the globe. However, recent discoveries of two novel human mammarenaviruses, Wenzhou Virus (WENV) and Plateau Pika Virus (PPV), in Asia and Southeast Asia show that mammarenaviruses are more widespread than previously thought. This editorial article aims to raise awareness about these emerging viruses, their genetic and ecological diversities, and clinical significance, and to encourage further study of these emerging viruses.
沙粒病毒科中的哺乳动物沙粒病毒属可感染哺乳动物，主要存在于全球啮齿动物的储主中。哺乳动物沙粒病毒可通过接触受感染的啮齿动物传播给人类，虽然感染通常无症状，但该属的某些成员可引起病毒性出血热，死亡率在 1%至 50%之间。这些病毒通常受到地理限制，这取决于其宿主储主的地理范围。淋巴细胞性脉络丛脑膜炎病毒 (LCMV) 曾被认为是全球范围内唯一存在的哺乳动物沙粒病毒。然而，最近在亚洲和东南亚发现了两种新型人类哺乳动物沙粒病毒，温州病毒 (WENV) 和高原鼠兔病毒 (PPV)，表明哺乳动物沙粒病毒的分布比以前认为的更为广泛。这篇社论文章旨在提高对这些新兴病毒及其遗传和生态多样性以及临床意义的认识，并鼓励对这些新兴病毒进行进一步研究。
