Jiangsu Key Laboratory for the Research and Utilization of Plant Resources, Institute of Botany, Jiangsu Province and Chinese Academy of Sciences, Nanjing, China.
Fengning PingAn High-Tech Industrial Co., Ltd, Chengde, China.
Nat Prod Res. 2024 Sep;38(18):3244-3252. doi: 10.1080/14786419.2023.2230606. Epub 2023 Jul 3.
Three 12, 8-guaianolide sesquiterpene lactones, including a new compound intybusin F (), and a new natural product cichoriolide I (), along with six known 12, 6-guaianolide compounds (-) were isolated from the roots of L. Their structures were determined by extensive spectroscopic analysis. The absolute configurations of new compounds were elucidated based on analysis of the experimental and calculated electronic circular dichroism spectra. Compounds , , , , showed significant effects on facilitating the glucose uptake in oleic acid plus high glucose-stimulated HepG2 cells at 50 μM. In addition, compounds , , , , exhibited obvious inhibitory effects against NO production, of them, compounds , , can significantly decrease the secretion of inflammatory cytokines (TNF-α, IL-6 and COX-2) levels in this hyperglycemic HepG2 cell model.
从 L. 的根部分离得到三种 12, 8-愈创木烷型倍半萜内酯，包括一种新化合物 intybusin F () 和一种新的天然产物 cichoriolide I ()，以及六种已知的 12, 6-愈创木烷型化合物 (-)。通过广泛的光谱分析确定了它们的结构。根据实验和计算的电子圆二色谱分析，确定了新化合物的绝对构型。化合物、、、、在 50 μM 时对促进油酸加高葡萄糖刺激的 HepG2 细胞中葡萄糖摄取有显著作用。此外，化合物、、、对 NO 生成有明显的抑制作用，其中，化合物、、可显著降低该高血糖 HepG2 细胞模型中炎症细胞因子 (TNF-α、IL-6 和 COX-2) 的分泌水平。
