Furgyik S, Grubb R, Kullander S, Sandahl B, Wingerup L, Eydal A
Acta Obstet Gynecol Scand. 1986;65(3):223-7. doi: 10.3109/00016348609155175.
All patients hospitalized in 1982 at the Department of Gynecology in Malmö because of malignancy of the cervix uteri attended an interview study concerning the presence of cervical cancer among their nearest relatives. In addition, these patients were questioned concerning earlier gonorrheal infection. The blood group was determined as also was the secretory status and Gm allotype. As a control group the families of the male consorts were used. Cervical cancer was found significantly more often in mothers of the patients (7.9%) than in the consorts' mothers (1.0%). Sisters, aged 20 or over, of the patients had cervical cancer significantly more often (7.5%) than sisters of the consorts (1.1%). Moreover, cervical cancer in mothers and/or sisters was found in 15.6% of the patients. In cases of invasive cancer or previously operated CIS, this figure was 17.5%. The patients did not differ significantly from the normal population regarding blood group or secretory status. A somewhat lower, although non-significant, frequency of Gm(1) allotype was found in patients with invasive cancer, compared with patients with CIS. Patients with a positive family history of cancer had more often had gonorrhea (24%) than patients with a negative family history (18%). The study indicates a multifactorial etiology for cervical cancer.
1982年，所有因子宫颈恶性肿瘤而入住马尔默妇科的患者都参加了一项关于其近亲中宫颈癌发病情况的访谈研究。此外，还询问了这些患者以前是否感染过淋病。测定了血型、分泌状态和Gm同种异型。以男性配偶的家属作为对照组。发现患者的母亲患宫颈癌的比例（7.9%）显著高于配偶的母亲（1.0%）。年龄在20岁及以上的患者姐妹患宫颈癌的比例（7.5%）显著高于配偶的姐妹（1.1%）。此外，15.6%的患者母亲和/或姐妹患有宫颈癌。在浸润性癌或既往接受过手术治疗的原位癌病例中，这一比例为17.5%。患者在血型或分泌状态方面与正常人群没有显著差异。与原位癌患者相比，浸润性癌患者中Gm(1)同种异型的频率略低，但差异不显著。有癌症家族史的患者感染淋病的比例（24%）高于无癌症家族史的患者（18%）。该研究表明宫颈癌的病因是多因素的。
