Copper-Catalyzed Asymmetric Hydroboration Reaction of Novel Methylene Isoindolinone Compounds through Microwave Irradiation and Their Antileishmanial and Antitoxoplasma Activities.

The aim of this study was devoted into molecular docking calculations to discover the potential antileishmania and antitoxoplasma activities of newly synthesized compounds obtained by applying a practical and simple method under microwave irradiation. All these compounds were tested in vitro for their biological activity against promastigotes, amastigotes, and tachyzoites. Compounds , , and were the most active against both promastigotes and amastigotes, with IC values of less than 0.4 μM mL. Compounds , , , and had a strong antitoxoplasma activity of less than 2.1 μM mL against . We can conclude that aromatic methyleneisoindolinones are potently active against both and . Further studies for mode of action evaluation are recommended. Compounds and are the best drug candidates for antileishmania and antitoxoplasma due to their SI values being over 13. The docking studies of compounds and against pteridine reductase 1 and enoyl acyl carrier protein reductase reveal that compound may be an effective antileishmanial and antitoxoplasma drug discovery initiative.