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Downregulated nuclear lncRNA NRON inhibits SHP2/Wnt/β-catenin signaling and cardiomyocyte differentiation during the development of Tetralogy of Fallot.

作者信息

Zhang Hui, Lu Lei, Li Chao, Li Hongdou, Tian Jie, Wang Hongyan

机构信息

Zhang Zhongjing School of Chinese Medicine; Henan Key Laboratory of Zhang Zhongjing Formulae and Herbs for Immunoregulation, Nanyang Institute of Technology, Nanyang, Henan 473004, China.

Department of Cardiology, Heart Centre; Ministry of Education Key Laboratory of Child Development and Disorders; National Clinical Research Center for Child Health and Disorders; Chongqing Key Laboratory of Pediatrics China International Science and Technology Cooperation Base of Child Development and Critical Disorders; Children's Hospital of Chongqing Medical University, Chongqing 400014, China.

出版信息

Genes Dis. 2022 Oct 23;10(3):750-752. doi: 10.1016/j.gendis.2022.10.010. eCollection 2023 May.

DOI:10.1016/j.gendis.2022.10.010
PMID:37396545
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10308166/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf32/10308166/6972a658f710/figs3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf32/10308166/b62ea83cd72d/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf32/10308166/e483a4347baf/figs1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf32/10308166/e14884546756/figs2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf32/10308166/6972a658f710/figs3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf32/10308166/b62ea83cd72d/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf32/10308166/e483a4347baf/figs1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf32/10308166/e14884546756/figs2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf32/10308166/6972a658f710/figs3.jpg

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引用本文的文献

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Mutations in genes related to myocyte contraction and ventricular septum development in non-syndromic tetralogy of Fallot.非综合征性法洛四联症中与心肌细胞收缩和室间隔发育相关基因的突变
Front Cardiovasc Med. 2023 Sep 28;10:1249605. doi: 10.3389/fcvm.2023.1249605. eCollection 2023.

本文引用的文献

1
Long non-coding RNA NRON is downregulated in HCC and suppresses tumour cell proliferation and metastasis.长非编码 RNA NRON 在 HCC 中下调，抑制肿瘤细胞增殖和转移。
Biomed Pharmacother. 2018 Aug;104:102-109. doi: 10.1016/j.biopha.2018.05.006. Epub 2018 May 15.
2
An episomal vector-based CRISPR/Cas9 system for highly efficient gene knockout in human pluripotent stem cells.基于附加型载体的 CRISPR/Cas9 系统在人多能干细胞中高效基因敲除。
Sci Rep. 2017 May 24;7(1):2320. doi: 10.1038/s41598-017-02456-y.
3
Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling.
通过对经典 Wnt 信号的时间调节，从人多能干细胞中产生健壮的心肌细胞分化。
Proc Natl Acad Sci U S A. 2012 Jul 3;109(27):E1848-57. doi: 10.1073/pnas.1200250109. Epub 2012 May 29.
4
Dephosphorylation of the nuclear factor of activated T cells (NFAT) transcription factor is regulated by an RNA-protein scaffold complex.去磷酸化的核因子活化 T 细胞 (NFAT) 转录因子是由 RNA-蛋白质支架复合物调节的。
Proc Natl Acad Sci U S A. 2011 Jul 12;108(28):11381-6. doi: 10.1073/pnas.1019711108. Epub 2011 Jun 27.
5
Surgery insight: late complications following repair of tetralogy of Fallot and related surgical strategies for management.手术洞察：法洛四联症修复术后的晚期并发症及相关处理手术策略
Nat Clin Pract Cardiovasc Med. 2006 Nov;3(11):611-22. doi: 10.1038/ncpcardio0682.