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Invest Ophthalmol Vis Sci. 2019 Nov 1;60(14):4670-4680. doi: 10.1167/iovs.19-27211.
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Long noncoding RNA LINC01089 predicts clinical prognosis and inhibits cell proliferation and invasion through the Wnt/β-catenin signaling pathway in breast cancer.长链非编码RNA LINC01089预测乳腺癌的临床预后并通过Wnt/β-连环蛋白信号通路抑制细胞增殖和侵袭。
Onco Targets Ther. 2019 Jun 21;12:4883-4895. doi: 10.2147/OTT.S208830. eCollection 2019.
3
Long non-coding RNA (lncRNA) small nucleolar RNA host gene 7 (SNHG7) promotes breast cancer progression by sponging miRNA-381.长链非编码 RNA（lncRNA）小核仁 RNA 宿主基因 7（SNHG7）通过海绵吸附 miRNA-381 促进乳腺癌的进展。
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Integrating of genomic and transcriptomic profiles for the prognostic assessment of breast cancer.整合基因组和转录组谱进行乳腺癌预后评估。
Breast Cancer Res Treat. 2019 Jun;175(3):691-699. doi: 10.1007/s10549-019-05177-0. Epub 2019 Mar 13.
6
Reduced expression of the lncRNA NRON is a potential hallmark of the CMV-amplified CD8+ T cell accumulations commonly seen in older humans.NRON 的表达降低是 CMV 扩增的 CD8+T 细胞在老年人中常见积聚的潜在标志。
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7
Long noncoding RNA MALAT1 suppresses breast cancer metastasis.长链非编码 RNA MALAT1 抑制乳腺癌转移。
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8
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Oncogene. 2018 Jul;37(30):4094-4109. doi: 10.1038/s41388-018-0250-z. Epub 2018 Apr 30.
10
NEAT1_2 functions as a competing endogenous RNA to regulate ATAD2 expression by sponging microRNA-106b-5p in papillary thyroid cancer.NEAT1_2 通过海绵吸附 microRNA-106b-5p 作为竞争性内源性 RNA 调节甲状腺乳头状癌中 ATAD2 的表达。
Cell Death Dis. 2018 Mar 7;9(3):380. doi: 10.1038/s41419-018-0418-z.

长链非编码RNA NRON通过调控miR-302b/SRSF2轴抑制乳腺癌发展。

Long non coding RNA NRON inhibited breast cancer development through regulating miR-302b/SRSF2 axis.

作者信息

Mao Qixin, Li Lianfang, Zhang Chongjian, Sun Yadong, Liu Shanqing, Li Yong, Shen Yan, Liu Zhenzhen

机构信息

Department of Breast Surgery, Affiliated Cancer Hospital of Zhengzhou University Zhengzhou, Henan, P. R. China.

出版信息

Am J Transl Res. 2020 Aug 15;12(8):4683-4692. eCollection 2020.

PMID:32913541
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7476134/
Abstract

AIMS

Long noncoding RNA NRON has been investigated in various tumors, such as hepatocellular carcinoma. However, the role of lncRNA NRON in breast cancer remains unclear. The aim of this study was to explore the function and mechanism of lncRNA NRON in breast cancer.

MATERIALS AND METHODS

Overexpression and knockdown vectors were constructed. Proliferation and invasion were measured to evaluate the function of lncRNA NRON. A dual-luciferase reporter assay was utilized to analyze the potential binding target of lncRNA NRON. A rescue experiment was performed to verify the relationship between lncRNA NRON and SRSF2.

RESULTS

Our results showed that the expression of lncRNA NRON was significantly downregulated in breast cancer tissues. Overexpression of lncRNA NRON significantly inhibited proliferation and invasion in breast cancer cell lines. Knockdown of lncRNA NRON promoted breast cancer development. We also provided evidence that lncRNA NRON negatively regulated miR-302b. Moreover, we identified SRSF2 as a downstream target of miR-302b.

CONCLUSION

Overall, we performed a comprehensive analysis to indicate that the lncRNA NRON/miR-302b/SRSF2 axis plays an important role in breast cancer. Our study is the first to prove that lncRNA NRON functions as a tumor suppressor in breast cancer.

摘要

目的

长链非编码RNA NRON已在多种肿瘤中得到研究，如肝细胞癌。然而，lncRNA NRON在乳腺癌中的作用仍不清楚。本研究的目的是探讨lncRNA NRON在乳腺癌中的功能及机制。

材料与方法

构建过表达和敲低载体。通过检测增殖和侵袭能力来评估lncRNA NRON的功能。利用双荧光素酶报告基因检测法分析lncRNA NRON的潜在结合靶点。进行挽救实验以验证lncRNA NRON与SRSF2之间的关系。

结果

我们的结果显示，lncRNA NRON在乳腺癌组织中的表达显著下调。lncRNA NRON的过表达显著抑制了乳腺癌细胞系的增殖和侵袭。lncRNA NRON的敲低促进了乳腺癌的发展。我们还提供了lncRNA NRON负向调控miR-302b的证据。此外，我们确定SRSF2是miR-302b的下游靶点。

结论

总体而言，我们进行了全面分析，表明lncRNA NRON/miR-302b/SRSF2轴在乳腺癌中起重要作用。我们的研究首次证明lncRNA NRON在乳腺癌中作为肿瘤抑制因子发挥作用。