Ishikawa K, Igarashi M, Yoshihara T
Acta Otolaryngol. 1986 Jul-Aug;102(1-2):118-23. doi: 10.3109/00016488609108655.
To characterize the functional role of the descending medial longitudinal fasciculus (d-MLF) in vestibular compensation, vestibulo-ocular and vestibulo-spinal balance functions were studied comparatively in the squirrel monkey. When a unilateral lesion was made on the d-MLF, the animals showed a slight head deviation to the intact side, slight locomotor ataxia and irregular spontaneous nystagmus. About 2 months later, the ipsilateral labyrinthectomy was placed, and the compensatory process was compared between 3 experimentals and 3 controls (labyrinthectomy without pre-lesion). During the acute stage of the vestibular compensation, locomotor deviation was clearly greater in experimentals than those in controls. However, no significant difference existed in the final attainment and maintenance of the balance. The same result was found in the spontaneous nystagmus, although the difference in the two groups was less remarkable.
为了明确下行内侧纵束（d-MLF）在前庭代偿中的功能作用，对松鼠猴的前庭眼动和前庭脊髓平衡功能进行了比较研究。当在d-MLF上进行单侧损伤时，动物表现出向完整侧的轻微头部偏斜、轻微运动性共济失调和不规则的自发性眼球震颤。大约2个月后，进行同侧迷路切除术，并比较3只实验组和3只对照组（无术前损伤的迷路切除术）之间的代偿过程。在前庭代偿的急性期，实验组的运动偏差明显大于对照组。然而，在平衡的最终达成和维持方面没有显著差异。在自发性眼球震颤方面也得到了相同的结果，尽管两组之间的差异不太明显。
