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含有源自犊牛和奶牛皱胃的凝乳酶和胃蛋白酶A的食品酶凝乳酶的安全性评估。

Safety evaluation of the food enzyme rennet containing chymosin and pepsin A from the abomasum of calves and cows.

作者信息

Lambré Claude, Barat Baviera José Manuel, Bolognesi Claudia, Cocconcelli Pier Sandro, Crebelli Riccardo, Gott David Michael, Grob Konrad, Lampi Evgenia, Mengelers Marcel, Mortensen Alicja, Rivière Gilles, Steffensen Inger-Lise, Tlustos Christina, Van Loveren Henk, Vernis Laurence, Zorn Holger, Roos Yrjö, Aguilera Jaime, Fernandez-Fraguas Cristina, Andryszkiewicz Magdalena, Cavanna Daniele, Liu Yi, Chesson Andrew

出版信息

EFSA J. 2023 Jun 30;21(6):e08084. doi: 10.2903/j.efsa.2023.8084. eCollection 2023 Jun.

Abstract

The food enzyme containing chymosin (EC 3.4.23.4) and pepsin A (EC 3.4.23.1) is prepared from the abomasum of calves and cows () by Chr. Hansen. The food enzyme is intended to be used in milk processing for cheese production and in milk processing for the production of fermented milk products. As no concerns arise from the animal source of the food enzyme, from its manufacture, and based on the history of safe use and consumption, the Panel considered that toxicological data were unnecessary and an estimation of dietary exposure was not required. A search for the similarity of the amino acid sequences of the two proteins (chymosin and pepsin A) to those of known allergens was made and one match with pig pepsin, a respiratory allergen, was found. The Panel considered that, under the intended conditions of use, the risk of allergic reactions upon dietary exposure cannot be excluded, but the likelihood is low. Based on the data provided, the Panel concluded that this food enzyme does not give rise to safety concerns under the intended conditions of use.

摘要

含有凝乳酶(EC 3.4.23.4)和胃蛋白酶A(EC 3.4.23.1)的食品酶由科汉森公司从犊牛和奶牛的皱胃中制备。该食品酶旨在用于奶酪生产的牛奶加工以及发酵乳制品生产的牛奶加工。由于该食品酶的动物来源、其生产过程以及基于安全使用和消费历史均未引发担忧,专家小组认为无需毒理学数据,也无需估计膳食暴露量。对这两种蛋白质(凝乳酶和胃蛋白酶A)的氨基酸序列与已知过敏原的相似性进行了搜索,发现与猪胃蛋白酶(一种呼吸道过敏原)有一个匹配。专家小组认为,在预期使用条件下,不能排除膳食暴露时发生过敏反应的风险,但可能性较低。根据提供的数据,专家小组得出结论,该食品酶在预期使用条件下不会引发安全问题。

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