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一名免疫功能低下患者同时感染人类猴痘和梅毒。

Human monkeypox coinfection with syphilis in an immunocompromised patient.

作者信息

Ordoñez-González Irvin, López-Zamora Berenice, Medina Gabriela, Reyes-Navarro Geraldine Vanessa, Navarro Alberto Ordinola, Cruz-Domínguez María Pilar, Vera-Lastra Olga, Saavedra Miguel Ángel

机构信息

Facultad de Medicina, Universidad Veracruzana, Veracruz.

Escuela Superior de Medicina, Instituto Politécnico Nacional, Mexico City.

出版信息

Dermatol Reports. 2022 Oct 27;15(2):9591. doi: 10.4081/dr.2022.9591. eCollection 2023 Jun 7.

DOI:10.4081/dr.2022.9591
PMID:37397408
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10312107/
Abstract

Monkeypox is a viral zoonosis from the Poxviridae family that spreads at an unprecedented rate. It is transmitted through contact with skin lesions, respiratory droplets, body fluids, and sexual contact. The diverse presentation of the disease leads to misdiagnosis. Thus, clinicians should have a high index of suspicion, mainly with diseases with skin lesions. The most vulnerable group to developing this disease are individuals with risky sexual relationships, sexually transmitted infections, or human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS). To date, only one case of coinfection with the monkeypox virus, syphilis, and HIV has been reported; however, no cases have been revealed in the Mexican territory. Herein we describe an unusual case of syphilis-monkeypox coinfection in an immunocompromised patient; despite his coinfection, he had a favorable prognosis. Furthermore, we attach allusive pictures of the natural evolution of dermatological lesions.

摘要

猴痘是一种由痘病毒科引起的病毒性人畜共患病,传播速度空前。它通过接触皮肤损伤、呼吸道飞沫、体液和性接触传播。该疾病的多样表现导致误诊。因此,临床医生应保持高度怀疑,主要针对有皮肤损伤的疾病。最易感染此病的人群是有危险性行为、性传播感染或感染人类免疫缺陷病毒/获得性免疫缺陷综合征(HIV/AIDS)的个体。迄今为止,仅报告了一例猴痘病毒、梅毒和HIV合并感染的病例;然而,墨西哥境内尚未发现此类病例。在此,我们描述了一例免疫功能低下患者发生梅毒 - 猴痘合并感染的罕见病例;尽管他合并感染,但预后良好。此外,我们附上了皮肤病损自然演变的相关图片。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1246/10312107/0562f5941d24/dr-15-2-9591-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1246/10312107/e5fef41c1162/dr-15-2-9591-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1246/10312107/65aef0831e7c/dr-15-2-9591-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1246/10312107/0562f5941d24/dr-15-2-9591-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1246/10312107/e5fef41c1162/dr-15-2-9591-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1246/10312107/65aef0831e7c/dr-15-2-9591-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1246/10312107/0562f5941d24/dr-15-2-9591-g003.jpg

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本文引用的文献

1
[Translated article] Monkeypox Virus Infection: A Case Report.[翻译文章] 猴痘病毒感染:一例报告。
Actas Dermosifiliogr. 2023 Jan;114(1):T83-T85. doi: 10.1016/j.ad.2022.06.020. Epub 2022 Nov 8.
2
Monkeypox: a new differential diagnosis when addressing genital ulcer disease.猴痘:生殖器溃疡疾病鉴别诊断的新关注点。
Br J Dermatol. 2022 Dec;187(6):1050-1052. doi: 10.1111/bjd.21834. Epub 2022 Sep 11.
3
The story behind the first few cases of monkeypox infection in non-endemic countries, 2022.2022 年,非流行国家出现首例猴痘感染病例的背景情况。
Cureus. 2023 Apr 24;15(4):e38083. doi: 10.7759/cureus.38083. eCollection 2023 Apr.
J Infect Public Health. 2022 Sep;15(9):970-974. doi: 10.1016/j.jiph.2022.07.014. Epub 2022 Aug 5.
4
Monkeypox - An emerging pandemic.猴痘——一种新出现的大流行病。
IDCases. 2022 Jul 26;29:e01587. doi: 10.1016/j.idcr.2022.e01587. eCollection 2022.
5
Monkeypox virus outbreak: a brief timeline.猴痘病毒疫情:简要时间线。
New Microbes New Infect. 2022 Jul 1;48:101004. doi: 10.1016/j.nmni.2022.101004. eCollection 2022 Jul.
6
The first case of monkeypox virus infection detected in Taiwan: awareness and preparation.台湾首例猴痘病毒感染病例检出:提高警觉,做好准备。
Int J Infect Dis. 2022 Sep;122:991-995. doi: 10.1016/j.ijid.2022.07.051. Epub 2022 Jul 25.
7
Human monkeypox coinfection with acute HIV: an exuberant presentation.人类猴痘合并急性 HIV 感染:一种表现活跃的病例。
Int J STD AIDS. 2022 Sep;33(10):936-938. doi: 10.1177/09564624221114998. Epub 2022 Jul 13.
8
Monkeypox and HIV/AIDS: When the outbreak faces the epidemic.猴痘与艾滋病毒/艾滋病:当疫情遭遇流行病时
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Monkeypox emerges on a global scale: A historical review and dermatologic primer.猴痘在全球范围内出现:历史回顾与皮肤科入门。
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Demographic and clinical characteristics of confirmed human monkeypox virus cases in individuals attending a sexual health centre in London, UK: an observational analysis.英国伦敦一家性健康中心就诊的确诊人感染猴痘病毒病例的人口统计学和临床特征:观察性分析。
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