Upreti Deepa, Rouzer Siara K, Bowring Abigail, Labbe Emma, Kumar Rosaline, Miranda Rajesh C, Mahnke Amanda H
Department of Neuroscience and Experimental Therapeutics, Texas A&M University School of Medicine, Bryan, TX, United States.
Front Neurosci. 2023 Jun 15;17:1182635. doi: 10.3389/fnins.2023.1182635. eCollection 2023.
Alcohol exposure in adulthood can result in inflammation, malnutrition, and altered gastroenteric microbiota, which may disrupt efficient nutrient extraction. Clinical and preclinical studies have documented convincingly that prenatal alcohol exposure (PAE) also results in persistent inflammation and nutrition deficiencies, though research on the impact of PAE on the enteric microbiota is in its infancy. Importantly, other neurodevelopmental disorders, including autism spectrum and attention deficit/hyperactivity disorders, have been linked to gut microbiota dysbiosis. The combined evidence from alcohol exposure in adulthood and from other neurodevelopmental disorders supports the hypothesis that gut microbiota dysbiosis is likely an etiological feature that contributes to negative developmental, including neurodevelopmental, consequences of PAE and results in fetal alcohol spectrum disorders. Here, we highlight published data that support a role for gut microbiota in healthy development and explore the implication of these studies for the role of altered microbiota in the lifelong health consequences of PAE.
成年期饮酒会导致炎症、营养不良以及胃肠微生物群改变，这可能会干扰营养物质的有效摄取。临床和临床前研究已令人信服地证明，产前酒精暴露（PAE）也会导致持续的炎症和营养缺乏，不过关于PAE对肠道微生物群影响的研究尚处于起步阶段。重要的是，其他神经发育障碍，包括自闭症谱系障碍和注意力缺陷多动障碍，都与肠道微生物群失调有关。成年期饮酒以及其他神经发育障碍的综合证据支持了这样一种假说，即肠道微生物群失调可能是一种病因特征，它会导致包括神经发育在内的PAE的负面发育后果，并导致胎儿酒精谱系障碍。在此，我们重点介绍支持肠道微生物群在健康发育中起作用的已发表数据，并探讨这些研究对微生物群改变在PAE终身健康后果中所起作用的启示。
