School of Medicine, University of North Dakota, Grand Forks, ND 58201, USA.
School of Medicine and Public Health, University of Wisconsin, Madison, WI 53706, USA.
Nutrients. 2022 Oct 11;14(20):4223. doi: 10.3390/nu14204223.
Prenatal alcohol exposure results in a spectrum of behavioral, cognitive, and morphological abnormalities collectively referred to as fetal alcohol spectrum disorder (FASD). FASD presents with significant phenotypic variability and may be modified by gestational variables such as maternal nutritional status. Iron serves a critical function in the development of and processes within central nervous system (CNS) structures. Gestational iron deficiency alters CNS development and may contribute to neurodevelopmental impairment in FASD. This review explores the relationship between iron deficiency and fetal alcohol spectrum disorder as described in small animal and human studies. Consideration is given to the pathophysiologic mechanisms linking iron homeostasis and prenatal alcohol exposure. Existing data suggest that iron deficiency contributes to the severity of FASD and provide a mechanistic explanation linking these two conditions.
产前酒精暴露导致一系列行为、认知和形态异常，统称为胎儿酒精谱系障碍（FASD）。FASD 表现出显著的表型变异性，并且可能受到妊娠变量的影响，如母体营养状况。铁在中枢神经系统（CNS）结构的发育和功能中起着至关重要的作用。妊娠期铁缺乏会改变 CNS 的发育，并可能导致 FASD 的神经发育障碍。这篇综述探讨了在小动物和人类研究中描述的缺铁与胎儿酒精谱系障碍之间的关系。考虑了将铁稳态与产前酒精暴露联系起来的病理生理机制。现有数据表明，缺铁会加重 FASD 的严重程度，并提供了一个将这两种情况联系起来的机制解释。
