胃肠道来源的体液因子对肝病相关轻度认知障碍的调节作用及磁共振成像研究进展：文献综述
Regulation of mild cognitive impairment associated with liver disease by humoral factors derived from the gastrointestinal tract and MRI research progress: a literature review.
作者信息
Sun Tianning, Feng Maohui, Manyande Anne, Xiang Hongbing, Xiong Jun, He Zhigang
机构信息
Department of Anesthesiology, Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health, Wuhan Clinical Research Center for Geriatric Anesthesia, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Department of Gastrointestinal Surgery, Wuhan Peritoneal Cancer Clinical Medical Research Center, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors, Hubei Cancer Clinical Study Center, Wuhan, Hubei, China.
出版信息
Front Neurosci. 2023 Jun 16;17:1206417. doi: 10.3389/fnins.2023.1206417. eCollection 2023.
Patients with liver disease are prone to various cognitive impairments. It is undeniable that cognitive impairment is often regulated by both the nervous system and the immune system. In this review our research focused on the regulation of mild cognitive impairment associated with liver disease by humoral factors derived from the gastrointestinal tract, and revealed that its mechanisms may be involved with hyperammonemia, neuroinflammation, brain energy and neurotransmitter metabolic disorders, and liver-derived factors. In addition, we share the emerging research progress in magnetic resonance imaging techniques of the brain during mild cognitive impairment associated with liver disease, in order to provide ideas for the prevention and treatment of mild cognitive impairment in liver disease.
肝病患者容易出现各种认知障碍。不可否认，认知障碍往往受到神经系统和免疫系统的共同调节。在本综述中，我们的研究聚焦于胃肠道来源的体液因子对肝病相关轻度认知障碍的调节作用，并揭示其机制可能涉及高氨血症、神经炎症、脑能量和神经递质代谢紊乱以及肝脏衍生因子。此外，我们分享了肝病相关轻度认知障碍期间脑磁共振成像技术的最新研究进展，以期为肝病轻度认知障碍的防治提供思路。
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