组蛋白翻译后修饰与DNA损伤反应。
Histone post-translational modification and the DNA damage response.
作者信息
Song Haoyun, Shen Rong, Liu Xiangwen, Yang Xuguang, Xie Kun, Guo Zhao, Wang Degui
机构信息
School of Basic Medical Sciences, Lanzhou University, Lanzhou, Gansu 730000, China.
出版信息
Genes Dis. 2022 Apr 22;10(4):1429-1444. doi: 10.1016/j.gendis.2022.04.002. eCollection 2023 Jul.
DNA is highly vulnerable to spontaneous and environmental timely damage in living cells. DNA damage may cause genetic instability and increase cancer risk if the damages are not repaired timely and efficiently. Human cells possess several DNA damage response (DDR) mechanisms to protect the integrity of their genome. Clarification of the mechanisms underlying the DNA damage response following lethal damage will facilitate the identification of therapeutic targets for cancers. Histone post-translational modifications (PTMs) have been indicated to play different roles in the repair of DNA damage. In this context, histone PTMs regulate recruitment of downstream effectors, and facilitate appropriate repair response. This review outlines the current understanding of different histone PTMs in response to DNA damage repair, besides, enumerates the role of new type PTMs such as histone succinylation and crotonylation in regulating DNA damage repair processes.
在活细胞中，DNA极易受到自发和环境造成的即时损伤。如果损伤不能及时有效地修复，DNA损伤可能会导致基因不稳定并增加癌症风险。人类细胞拥有多种DNA损伤反应（DDR）机制来保护其基因组的完整性。阐明致死性损伤后DNA损伤反应的潜在机制将有助于确定癌症的治疗靶点。组蛋白翻译后修饰（PTMs）已被表明在DNA损伤修复中发挥不同作用。在这种情况下，组蛋白PTMs调节下游效应物的募集，并促进适当的修复反应。本综述概述了目前对不同组蛋白PTMs在DNA损伤修复反应中的理解，此外，还列举了新型PTMs如组蛋白琥珀酰化和巴豆酰化在调节DNA损伤修复过程中的作用。
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