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GPR39 deorphanization: The long and winding road to eicosanoids and a crosstalk between GPR39 and hedgehog signaling in angiogenesis.

作者信息

Doboszewska Urszula, Maret Wolfgang, Wlaź Piotr

机构信息

Department of Pharmacobiology, Jagiellonian University Medical College, Kraków PL 30-688, Poland.

Department of Nutritional Sciences, School of Life Course and Population Sciences, Faculty of Life Sciences and Medicine, King's College London, London SE1 9NH, United Kingdom.

出版信息

Proc Natl Acad Sci U S A. 2023 Jul 11;120(28):e2308227120. doi: 10.1073/pnas.2308227120. Epub 2023 Jul 3.

DOI:10.1073/pnas.2308227120
PMID:37399396
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10334797/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d0f/10334797/ac2b82847419/pnas.2308227120fig01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d0f/10334797/ac2b82847419/pnas.2308227120fig01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d0f/10334797/ac2b82847419/pnas.2308227120fig01.jpg

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本文引用的文献

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Proc Natl Acad Sci U S A. 2023 Jan 3;120(1):e2208541120. doi: 10.1073/pnas.2208541120. Epub 2022 Dec 27.
2
Control of coronary vascular resistance by eicosanoids via a novel GPCR.通过新型 G 蛋白偶联受体对冠状动脉阻力的控制。
Am J Physiol Cell Physiol. 2022 May 1;322(5):C1011-C1021. doi: 10.1152/ajpcell.00454.2021. Epub 2022 Apr 6.
3
Reply to Doboszewska et al.: The many faces of G-protein-coupled receptor 39.
回复多博谢夫斯卡等人：G蛋白偶联受体39的多面性
Proc Natl Acad Sci U S A. 2023 Jul 11;120(28):e2308643120. doi: 10.1073/pnas.2308643120. Epub 2023 Jul 3.
Metabolism pathways of arachidonic acids: mechanisms and potential therapeutic targets.
花生四烯酸的代谢途径：机制与潜在治疗靶点。
Signal Transduct Target Ther. 2021 Feb 26;6(1):94. doi: 10.1038/s41392-020-00443-w.
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Oral 15-Hydroxyeicosatetraenoic Acid Induces Pulmonary Hypertension in Mice by Triggering T Cell-Dependent Endothelial Cell Apoptosis.15-羟基二十碳四烯酸通过触发 T 细胞依赖性内皮细胞凋亡诱导小鼠肺动脉高压。
Hypertension. 2020 Sep;76(3):985-996. doi: 10.1161/HYPERTENSIONAHA.120.14697. Epub 2020 Jul 27.
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12/15-Lipoxygenase gene knockout severely impairs ischemia-induced angiogenesis due to lack of Rac1 farnesylation.12/15-脂氧合酶基因敲除由于 Rac1 法尼基化缺乏严重损害缺血诱导的血管生成。
Blood. 2011 Nov 17;118(20):5701-12. doi: 10.1182/blood-2011-04-347468. Epub 2011 Aug 12.
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Crosstalk of the group IIa and IIb metals calcium and zinc in cellular signaling.IIa族和IIb族金属钙和锌在细胞信号传导中的相互作用。
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