Department of Ophthalmology, American University of Beirut Medical Center, Beirut, Lebanon.
Dr. Agarwal's Eye Hospital, Chennai, India; and.
Cornea. 2023 Nov 1;42(11):1461-1464. doi: 10.1097/ICO.0000000000003328. Epub 2023 Jun 23.
The aim of this study was to describe a new technique to facilitate the insertion of corneal allogenic intrastromal ring segments.
A single-segment corneal allogenic intrastromal ring segment (CAIRS) was trephined from donor corneas and allowed to markedly dehydrate for 75 minutes before the start of the procedure with a room humidity of 35% to 45%. The duration of the insertion step and the intrastromal segment size at 1 week as measured by optical coherence tomography were compared with previously performed single-segment CAIRS procedures using the conventional technique.
A total of 41 eyes of 36 patients underwent 1-segment CAIRS insertion of the same trephination size (750 µm). Fifteen eyes underwent the conventional insertion procedure, and 26 eyes had a dehydrated segment inserted. The time taken to insert the CAIRS analyzed by surgical video recording starting after the femtosecond tunnel creation and initiation of the insertion to the segment ironing step was 282 ± 103 and 97 ± 23 seconds for the conventional and the dehydrated segment technique, respectively ( P < 0.001). Anterior segment optical coherence tomography performed 1 week postoperatively revealed similar segment thickness and width of 471.3 ± 54.1 μm and 1285.1 ± 191.0 μm for the conventional allogenic segments and 483.4 ± 58.3 μm and 1227.2 ± 165.2 μm for the dehydrated segments ( P = 0.515 and 0.314, respectively).
Markedly dehydrated corneal allogenic segments are easier and faster to insert than the nondehydrated ones while maintaining similar sizes intrastromally. This dehydration technique makes the procedure similar to the one with synthetic segments and hence reduces the learning curve.
本研究旨在描述一种新的技术,以促进角膜同种异体基质环段的插入。
从供体角膜中切取单个角膜同种异体基质环段(CAIRS),并在开始手术前将其在 35%至 45%的室内湿度下显著脱水 75 分钟。通过光学相干断层扫描测量插入步骤的持续时间和第 1 周时的基质段大小,并与使用传统技术进行的先前的单个 CAIRS 程序进行比较。
共有 36 名患者的 41 只眼接受了相同直径(750μm)的 1 段 CAIRS 插入。15 只眼接受了常规插入程序,26 只眼插入了脱水段。通过手术录像分析,从飞秒隧道创建和插入开始到段压平步骤开始后开始插入 CAIRS 的时间分别为 282±103 秒和 97±23 秒,分别用于传统和脱水段技术(P<0.001)。术后 1 周行眼前节光学相干断层扫描显示,常规同种异体段的段厚度和宽度分别为 471.3±54.1μm和 1285.1±191.0μm,脱水段分别为 483.4±58.3μm和 1227.2±165.2μm(P=0.515 和 0.314)。
与非脱水的同种异体角膜段相比,明显脱水的同种异体角膜段更容易且更快插入,同时在基质内保持相似的大小。这种脱水技术使该过程类似于使用合成段的过程,从而降低了学习曲线。