Department of Nephrology and Hypertension, Regenerative Medicine Center Utrecht, University Medical Center Utrecht, Utrecht, The Netherlands.
Department of Development and Regeneration, Cluster Woman and Child, Laboratory of Pediatric Nephrology, KU Leuven, Leuven, Belgium.
Pediatr Nephrol. 2024 Feb;39(2):383-395. doi: 10.1007/s00467-023-06039-0. Epub 2023 Jul 3.
The endogenous capacity of the kidney to repair is limited, and generation of new nephrons after injury for adequate function recovery remains a need. Discovery of factors that promote the endogenous regenerative capacity of the injured kidney or generation of transplantable kidney tissue represent promising therapeutic strategies. While several encouraging results are obtained after administration of stem or progenitor cells, stem cell secretome, or extracellular vesicles in experimental kidney injury models, very little data exist in the clinical setting to make conclusions about their efficacy. In this review, we provide an overview of the cutting-edge knowledge on kidney regeneration, including pre-clinical methodologies used to elucidate regenerative pathways and describe the perspectives of regenerative medicine for kidney patients.
肾脏自身的修复能力有限，因此需要产生新的肾单位来实现足够的功能恢复。发现能够促进受损肾脏内源性再生能力或产生可移植肾组织的因子代表了很有前途的治疗策略。虽然在实验性肾损伤模型中给予干细胞或祖细胞、干细胞分泌组或细胞外囊泡后获得了一些令人鼓舞的结果，但在临床环境中几乎没有关于其疗效的结论性数据。在这篇综述中，我们概述了肾脏再生的最新知识，包括用于阐明再生途径的临床前方法，并描述了再生医学在肾脏疾病患者中的应用前景。
