硝苯地平过量

Nifedipine overdose.

作者信息

Herrington D M, Insley B M, Weinmann G G

出版信息

Am J Med. 1986 Aug;81(2):344-6. doi: 10.1016/0002-9343(86)90276-7.

Abstract

A 59-year-old man ingested 900 mg of nifedipine. Profound hypotension, sinus and atrioventricular node dysfunction, and hyperglycemia resulted. The patient's condition responded favorably to aggressive treatment with intravenous fluids, calcium, and dopamine. Similar effects and response to therapy have been reported in 17 cases of verapamil overdose and are briefly summarized. The effects of nifedipine overdose are discussed, and preliminary recommendations about its management are offered. With increasing use of nifedipine and other calcium channel blockers, more incidents of overdose can be expected.

摘要

一名59岁男性摄入了900毫克硝苯地平。结果出现了严重低血压、窦房结和房室结功能障碍以及高血糖。患者的病情通过静脉输液、钙剂和多巴胺积极治疗后有良好反应。在17例维拉帕米过量病例中也报告了类似的效应和治疗反应，并进行了简要总结。讨论了硝苯地平过量的影响，并给出了关于其处理的初步建议。随着硝苯地平和其他钙通道阻滞剂的使用增加，预计会有更多过量事件发生。