Jafari Vianna F, Mossayebi Zahra, Allison-Logan Stephanie, Shabani Sadegh, Qiao Greg G
Department of Chemical Engineering, The University of Melbourne, Parkville, VIC 3010, Australia.
Chemistry. 2023 Sep 21;29(53):e202301767. doi: 10.1002/chem.202301767. Epub 2023 Aug 4.
Machines can revolutionize the field of chemistry and material science, driving the development of new chemistries, increasing productivity, and facilitating reaction scale up. The incorporation of automated systems in the field of polymer chemistry has however proven challenging owing to the demanding reaction conditions, rendering the automation setup complex and costly. There is an imminent need for an automation platform which uses fast and simple polymerization protocols, while providing a high level of control on the structure of macromolecules via precision synthesis. This work combines an oxygen tolerant, room temperature polymerization method with a simple liquid handling robot to automatically prepare precise and high order multiblock copolymers with unprecedented livingness even after many chain extensions. The highest number of blocks synthesized in such a system is reported, demonstrating the capabilities of this automated platform for the rapid synthesis and complex polymer structure formation.
机器可以彻底改变化学和材料科学领域，推动新化学的发展，提高生产力，并促进反应规模扩大。然而，由于反应条件苛刻，在聚合物化学领域引入自动化系统已被证明具有挑战性，这使得自动化设置复杂且成本高昂。迫切需要一个自动化平台，该平台使用快速简单的聚合方案，同时通过精确合成对大分子结构提供高水平的控制。这项工作将一种耐氧室温聚合方法与一个简单的液体处理机器人相结合，以自动制备精确且高阶的多嵌段共聚物，即使经过多次链延伸后仍具有前所未有的活性。报道了在这样一个系统中合成的嵌段的最大数量，证明了这个自动化平台在快速合成和形成复杂聚合物结构方面的能力。
