Imbasciati E, Pardi G, Capetta P, Ambroso G, Bozzetti P, Pagliari B, Ponticelli C
Am J Nephrol. 1986;6(3):193-8. doi: 10.1159/000167114.
We describe 19 pregnancies in 18 women with chronic renal disease and plasma creatinine greater than or equal to 1.6 mg/dl before pregnancy. There were 2 spontaneous abortions (11th and 21st week), 2 therapeutic abortions (18th and 19th week), 1 stillbirth (30th week), 1 neonatal death (31st week) and 13 live births, 7 of them were preterm. Nine cesarean sections were done. Serial determinations of plasma creatinine during pregnancy showed a trend to decrease during the first half and to increase during the second half of pregnancy. The effect of pregnancy on the progression of renal failure was evaluated in 14 patients by comparing the linear regression lines of reciprocal plasma creatinine versus time before and after pregnancy. In 5 patients the rate of progression worsened after pregnancy. Our data indicate that women with chronic renal failure may have a successful pregnancy, but one third of them will have an accelerated rate of progression of the disease.
我们描述了18例患有慢性肾病且妊娠前血浆肌酐大于或等于1.6mg/dl的女性的19次妊娠情况。其中有2例自然流产（分别在第11周和第21周），2例治疗性流产（分别在第18周和第19周），1例死产（第30周），1例新生儿死亡（第31周）以及13例活产，其中7例为早产。共进行了9次剖宫产。孕期血浆肌酐的系列测定显示，妊娠前半期呈下降趋势，后半期呈上升趋势。通过比较妊娠前后血浆肌酐倒数与时间的线性回归线，对14例患者评估了妊娠对肾衰竭进展的影响。5例患者在妊娠后疾病进展速率加快。我们的数据表明，患有慢性肾衰竭的女性可能成功妊娠，但其中三分之一的患者疾病进展速率会加快。
