China Aerospace Science & Industry Corporation 731 Hospital, Beijing, China.
Eur Rev Med Pharmacol Sci. 2023 Jun;27(12):5862-5868. doi: 10.26355/eurrev_202306_32825.
This study aims to evaluate the value of microbial rapid on-site evaluation (M-ROSE) of sepsis, and septic shock caused by pulmonary infection.
Thirty-six patients with sepsis and septic shock due to hospital-acquired pneumonia were analyzed. Accuracy and time were compared with M-ROSE, traditional culture, and next-generation sequencing (NGS).
A total of 48 strains of bacteria and 8 strains of fungi were detected by bronchoscopy in 36 patients. The accuracy rate of bacteria and fungi was 95.8% and 100%, respectively. M-ROSE took an average of 0.34±0.01 hours, much faster than NGS (22h±0.01 h, p<0.0001) and traditional culture time (67.50±0.91 h, p<0.0001).
M-ROSE may quickly identify common bacteria and fungi, so it may be a useful method for the etiological diagnosis of sepsis and septic shock caused by pulmonary infection.
本研究旨在评估微生物快速现场评估（M-ROSE）在医院获得性肺炎引起的脓毒症和感染性休克中的价值。
分析了 36 例因医院获得性肺炎引起的脓毒症和感染性休克患者。与 M-ROSE、传统培养和下一代测序（NGS）比较了准确性和时间。
36 例患者经支气管镜共检出 48 株细菌和 8 株真菌。细菌和真菌的准确率分别为 95.8%和 100%。M-ROSE 平均用时 0.34±0.01 小时，明显快于 NGS（22h±0.01 h，p<0.0001）和传统培养时间（67.50±0.91 h，p<0.0001）。
M-ROSE 可能快速鉴定常见细菌和真菌，因此可能是肺部感染引起的脓毒症和感染性休克病因诊断的有用方法。
