Guo Xiaofan, Osouli Sima, Shahripour Reza Bavarsad
Department of Neurology, Loma Linda University, Loma Linda, CA, 92354, USA.
Department of Neurology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, 1516745811, Iran.
Adv Biol (Weinh). 2023 Oct;7(10):e2300179. doi: 10.1002/adbi.202300179. Epub 2023 Jul 4.
Radiation therapy (RT) causes radiation-induced vasculopathy, which requires clinicians to identify and manage this side effect in pediatric and adult patients. This article reviews previous findings about the pathophysiology of RT-induced vascular injury, including endothelial cell injury, oxidative stress, inflammatory cytokines, angiogenic pathways, and remodeling. The vasculopathy is categorized into ischemic vasculopathy, hemorrhagic vasculopathy, carotid artery injury, and other malformations (cavernous malformations and aneurysms) in populations of pediatric and adult patients separately. The prevention and management of this RT-induced side effect are also discussed. The article summarizes the distribution and risk factors of different types of RT-induced vasculopathy. This will help clinicians identify high-risk patients with corresponding vasculopathy subtypes to deduce prevention and treatment strategies accordingly.
放射治疗（RT）会引发放射性血管病变，这就要求临床医生在儿科和成年患者中识别并处理这种副作用。本文回顾了先前关于RT诱导血管损伤病理生理学的研究结果，包括内皮细胞损伤、氧化应激、炎性细胞因子、血管生成途径和重塑。在儿科和成年患者群体中，血管病变分别被分类为缺血性血管病变、出血性血管病变、颈动脉损伤以及其他畸形（海绵状畸形和动脉瘤）。本文还讨论了这种RT诱导副作用的预防和管理。文章总结了不同类型RT诱导血管病变的分布情况和风险因素。这将有助于临床医生识别患有相应血管病变亚型的高危患者，从而据此推断预防和治疗策略。
