Zöllner C, Büsing C M
Am J Otol. 1986 Jul;7(4):289-93.
In our experiments on the hypotympanum of the pig, resorbable porous tricalcium phosphate ceramic has proved to be serviceable for reducing radical mastoidectomy cavities and as a substitute for osseous walls. For our initial clinical trials with porous tricalcium phosphate ceramic in middle ear surgery, we had implants made especially for the purposes of replacing osseous walls and reducing radical mastoidectomy cavities. When implants have been used to replace osseous walls, insufficient ventilation of the tympanic cavity has frequently coincided with complications in the covering between implant and auditory canal. Follow-up operations have afforded opportunities for histologic examination of fifteen implants, which served as wall replacements for nine to thirty months. There were only the slightest traces of resorption and replacement by bone. In contrast with our findings on the replacement of walls with ceramic implants, postoperative observation for periods of up to four years has shown that granules of porous tricalcium phosphate ceramic are well suited to reducing radical mastoidectomy cavities.
在我们对猪鼓室下隐窝的实验中，可吸收性多孔磷酸三钙陶瓷已被证明可用于缩小乳突根治术腔，并可作为骨壁的替代品。在我们最初使用多孔磷酸三钙陶瓷进行中耳手术的临床试验中，我们定制了植入物，专门用于替代骨壁和缩小乳突根治术腔。当使用植入物替代骨壁时，鼓室通气不足常常与植入物和耳道之间覆盖物的并发症同时出现。后续手术为对15个植入物进行组织学检查提供了机会，这些植入物作为骨壁替代品使用了9至30个月。仅有极轻微的吸收痕迹和骨替代现象。与我们使用陶瓷植入物替代骨壁的研究结果不同，长达四年的术后观察表明，多孔磷酸三钙陶瓷颗粒非常适合缩小乳突根治术腔。
