Department of Neurology, Affiliated Hospital of Xuzhou Medical University, No. 99 Huaihai West Road, Quanshan Distric, Xuzhou, Jiangsu, China.
Department of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, China.
Neurol Sci. 2023 Nov;44(11):3877-3884. doi: 10.1007/s10072-023-06933-3. Epub 2023 Jul 5.
Myasthenia gravis (MG) is a classic autoimmune neuromuscular disease with strong clinical heterogeneity. The concept of subgroup classification was proposed to guide the precise treatment of MG. Subgroups based on serum antibodies and clinical features include ocular MG, early-onset MG with AchR antibodies, late-onset MG with AchR antibodies, thymoma-associated MG, MuSK-associated MG, LRP4-associated MG, and seronegative MG. However, reliable objective biomarkers are still needed to reflect the individualized response to therapy. MicroRNAs (miRNAs) are small non-coding RNA molecules which can specifically bind to target genes and regulate gene expression at the post-transcriptional level, and then influence celluar biological processes. MiRNAs play an important role in the pathogenesis of autoimmune diseases, including MG. Several studies on circulating miRNAs in MG have been reported. However, there is rare systematic review to summarize the differences of these miRNAs in different subgroups of MG. Here, we summarize the potential role of circulating miRNAs in different subgroups of MG to promote personalized medicine.
重症肌无力（MG）是一种经典的自身免疫性神经肌肉疾病，具有很强的临床异质性。亚组分类的概念被提出，以指导 MG 的精准治疗。基于血清抗体和临床特征的亚组包括眼肌型 MG、抗 AChR 抗体阳性的早发型 MG、抗 AChR 抗体阳性的晚发型 MG、胸腺瘤相关 MG、MuSK 相关 MG、LRP4 相关 MG 和血清阴性 MG。然而，仍需要可靠的客观生物标志物来反映治疗的个体化反应。微小 RNA（miRNA）是一种小的非编码 RNA 分子，可以特异性地与靶基因结合，并在转录后水平调节基因表达，从而影响细胞的生物学过程。miRNA 在自身免疫性疾病的发病机制中发挥着重要作用，包括 MG。已有多项关于 MG 循环 miRNA 的研究报道。然而，很少有系统评价来总结这些 miRNA 在 MG 不同亚组中的差异。在这里，我们总结了循环 miRNA 在 MG 不同亚组中的潜在作用，以促进个体化医学。
